Latest research on Insulin detemir

Insulin detemir is a long-acting human insulin analogue used to maintain basal levels of insulin in diabetic individuals. It is produced using recombinant DNA technology in yeast cells. This insulin analogue has a 14-C fatty acid, myristic acid, bound to the lysine amino acid at position B29. The myristoyl side chain increases self-association and albumin binding. This along with slow systemic absorption from the injection site prolongs distribution of the hormone into tissues and results in a long duration of action. Novo Nordisk markets insulin detemir under the trade name Levemir.

Latest findings

Insulin detemir is another bioengineered insulin developed by removing a Threonine and acylating a lysine residue with 14-carbon fatty acid, both in the B chain. [source, 2016]
BEGIN was an open-label, treat-to-target, non-inferiority, multicentric trial assessing adult patients with type 1 DM who had been treated with basal-bolus insulin for at least 1 year (70 % receiving insulin glargine and 19 % receiving Insulin detemir at screening) [23]. [source, 2016]
Finally, fracture risk in users of different types of basal insulins (Insulin detemir, insulin glargine, NPH insulin) was assessed. [source, 2016]
The long-acting group included patients who received long acting insulin (e.g., insulin glargine, Insulin detemir) or intermediate-acting insulin (e.g., isophane) and did not have a claim for any other types of insulin for 100 days after their long-acting insulin claim. [source, 2016]
Currently, the most efficient glucose-lowering treatments for type 1 diabetes (T1DM) and type 2 diabetes (T2DM) in the event of oral antidiabetic drug failure are insulin glargine (IGla) and Insulin detemir (IDet). [source, 2015]
This patient was earlier taking Glibenclamide, sitagliptin, and Insulin detemir (20 units). [source, 2015]
IV insulin Aspart with Insulin detemir was studied by Dungan et al. to determine whether an insulin algorithm could be used in a similar manner in the setting of diabetes and stress hyperglycemia following cessation of IV (IV) insulin after cardiac surgery and they found use of IV insulin Aspart to be safe in patients after cardiac surgery [26]. [source, 2015]
But the A1Chieve,9 a metacentric non-interventional study on 60000 diabetics in 28 countries, across 4 continents, over 24-weeks, evaluated the safety and effectiveness of Insulin detemir, biphasic insulin Aspart, and insulin Aspart (Novo Nordisk Inc., Plainsboro, NJ, USA), in people with type 2 diabetes mellitus, concluded that starting or switching to insulin analogues was associated with improvement in glycemic control with low frequency of hypoglycemia. [source, 2015]
The acylation of lysine B29 also participates in the protraction mechanism, permitting binding to albumin in the bloodstream, like Insulin detemir [9]. [source, 2015]
From September 2010 to July 2012, we enrolled Korean patients aged ≥18 years who had been diagnosed with type 2 diabetes for 6 months according to the 1999 World Health Organization criteria12, had been treated with a stable dose of basal insulin (insulin glargine or Insulin detemir) for ≥2 months, and had a verified HbA1c level between 7.5 and 10.0%. [source, 2015]