Latest research on Irbesartan

Irbesartan is an angiotensin receptor blocker (ARB) used mainly for the treatment of hypertension. It competes with angiotensin II for binding at the AT1 receptor subtype. Unlike ACE inhibitors, ARBs do not have the adverse effect of dry cough. The use of ARBs is pending revision due to findings from several clinical trials suggesting that this class of drugs may be associated with a small increased risk of cancer.

Latest findings

Disappointing results from large phase III HFPEF clinical trials, including the Irbesartan in Heart Failure with Preserved Ejection Fraction Study (I-PRESERVE) [3], Perindopril for Elderly People with Chronic Heart Failure (PEP-CHF) [4], Candersartan in Heart Failure-Assessment of Reduction in Mortality and Morbidity-Preserved Study (CHARM-Preserved) [5], and Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist (TOPCAT) [6], underscore our incomplete understanding of this disease. [source, 2016]
His regular medications included Irbesartan 150 mg once a day, Amlodipine 5 mg once a day, Simvastatin 20 mg once a day, alfacalcidol 0.25 microgram once a day and Sevelamer 800 mg three times a day with meals. [source, 2016]
Irbesartan, Candesartan and Valsartan displayed high concentration (Table 6). [source, 2016]
In addition, Irbesartan 150 mg, Spironolactone 25 mg, verapamil 240 mg, and Carvedilol 25 mg were administered. [source, 2016]
However, the levels of serum creatinine were not significantly changed (p > 0.05) in all drug-treated groups in contrast to that in the Thy-1 group, which demonstrated that Irbesartan and Shenhua Tablet of any dose in this study were unable to reduce the level of serum creatinine in rats with anti-Thy-1 nephritis (Fig. 2). [source, 2016]
The non-standardized product number in People’s Liberation Army is F01012 (2006). Irbesartan was provided by Hangzhou Sanofi-Aventis Minsheng Pharmaceutical Co., Ltd. [source, 2016]
Many drugs, ranging from diuretics (Indapamide, Furosemide, Amiloride), sympathoplegic agents (Clonidine, Reserpine), renin inhibitor (Aliskiren), angiotensin converting enzymes (ACE) inhibitors (Enalapril, Captopril, Quinapril), angiotensin receptors blockers (ARBs—Losartan, Irbesartan, Olmesartan), Calcium channel blockers (Nifedipine, Verapamil, Diltiazem), α-adrenergic blockers (Prazosin, Doxazosin), β-adrenergic blockers (Nebivolol, Atenolol) to vasodilators (Minoxidil, sodium nitroprusside), are used to manage blood pressure levels in hypertensive patients (Archer, 2000; Susalit et al., 2011). [source, 2016]
His medical history was significant for hypertension controlled on Bisoprolol and Irbesartan, dyslipidemia treated with Atorvastatin, and a transient cerebral ischemic attack 5 months prior to presentation for which he was put on Aspirin and Clopidogrel. [source, 2016]
Phenacetin, coumarin, Midazolam, Tolbutamide, S-Mephenytoin, Metoprolol, Chlorzoxazone, and the standards for their metabolites, including Acetaminophen, 7-hydroxyl coumarin, 1-hydroxyl Midazolam, 4-hydroxyl Tolbutamide, 4-hydroxyl mephenytoin, α-hydroxyl Metoprolol, 6-hydroxyl Chlorzoxazone, and Irbesartan (the internal standard), were purchased from Sigma-Aldrich (Shanghai, China). [source, 2016]
The reactions were stopped by adding 0.2 mL ice-cold acetonitrile, which contains Irbesartan (114.9 ng/mL) as the internal standard. [source, 2016]