Latest research on Lantus

Insulin glargine is produced by recombinant DNA technology using a non-pathogenic laboratory strain of Escherichia coli (K12) as the production organism. It is an analogue of human insulin made by replacing the asparagine residue at position A21 of the A-chain with glycine and adding two arginines to the C-terminus (positions B31 and 32) of the B-chain. The resulting protein is soluble at pH 4 and forms microprecipitates at physiological pH 7.4. Small amounts of insulin glargine are slowly released from microprecipitates giving the drug a long duration of action (up to 24 hours) and no pronounced peak concentration.

Lantus indications

To test the effect of insulin, 30 unit/kg Lantus (insulin glargine, a long-acting insulin) was injected daily one week after STZ-induction for 10 days before renal ischemia-reperfusion. [source, 2014]
To determine the effects of the test compounds on fasting blood glucose (FBG) levels, animals were randomly divided into experimental groups and after an overnight fast were subjected to a single s.c. injection of vehicle (PBS), insulin glargine (Lantus), or DM199. [source, 2014]
To examine whether any AEs of treatments were altered by discontinuation of Rosiglitazone and initiation of insulin therapy (Lantus, Sanofi-Aventis, Bridgewater, NJ) at the time of PO, the effect of treatment group, after adjusting for sex, race/ethnicity, age at baseline, and economic status, was analyzed separately before and after PO or censoring (i.e., study termination without PO). [source, 2013]
This international, multicenter, randomized, and open-label trial with a 2 × 2 factorial design evaluated the protective effects of n-3 PUFAs in a daily dose of 1 g versus corn oil, and Insulin Glargine (Lantus) versus standard care, on cardiovascular mortality and morbidity during 6 years of followup in 12 536 high-risk subjects with impaired fasting glucose, impaired glucose tolerance, or early type 2 diabetes. [source, 2012]
To eliminate possible confounding effects of STZ, insulin was immediately given using a long-term insulin preparation (Lantus Insulin glargine injection; sanofi-aventis Canada, Laval, Canada) at a dose of 5–15 units per mouse per day to maintain the blood glucose levels between 5–12 mmol/l when hyperglycemia was greater than 20 mmol/l on day 3 after STZ treatment in wild-type mice. [source, 2009]