Latest research on Levothyroxine

The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (monoiodotyrosine) and the coupling of iodotyrosines (diiodotyrosine) in the thyroglobulin. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form triiodothyronine which exerts a broad spectrum of stimulatory effects on cell metabolism. [PubChem]

Levothyroxine indications

There is no indication for routine measurement of free T4 concentrations in patients on L-T4 when TSH is being monitored, unless the physician is concerned that the patient is not compliant with the prescribed dose. [source, 2016]
In general, long-term treatment with L-T4 should be individualized and balanced against the potential risk of adverse effects during the follow-up in patients who are both at high risk of recurrence and at high risk of adverse effects. [source, 2016]
This is particularly relevant in the elderly population who are at increased risk for both cancer progression and L-T4 therapy side effects.12 [source, 2016]
Generally, patient preferences depend on the following factors for the treatment of Thyroid diseases: (a) cancerisation; (b) recurrence; (c) cost, including examination, surgery, medical therapy and re-examination; (d) psychological burden; (e) lifelong Levothyroxine replacement; (f) tolerance of medical therapies and associated side effects, such as anti-Thyroid gland medicine; (g) education level; (h) income; and (i) medical insurance. [source, 2016]
Considering that the etiology of the majority of SHO cases is thyroiditis, it is evident that even short-term Levothyroxine treatment exerts anti-inflammatory and anti-apoptotic effects in these patients. [source, 2015]
Significant enlargement of thyroid nodule during observation or L-T4 pharmacotherapy is an urgent indication for surgery because it may indicate neoplastic growth. [source, 2015]
The effect of L-T4 replacement would be useful to verify the causal association between endothelial dysfunction and SH. [source, 2015]
However, current evidence remains insufficient to confirm the beneficial effect of L-T4 therapy on patients with SH. [source, 2015]
The study concluded that the alteration of lipid profile, inflammatory status and the direct effect of thyroid hormone in patients with SH jointly contributed to their impaired endothelial dependent vasodilation and early L-T4 replacement therapy may be advisable to slow down atherogenesis. [source, 2015]
An appropriately powered randomized controlled trial of L-T4 in SH examining vascular outcomes is warranted, particularly to value the effect for the older patients (75). [source, 2015]