Latest research on Linezolid

Linezolid is a synthetic antibiotic, the first of the oxazolidinone class, used for the treatment of infections caused by multi-resistant bacteria including streptococcus and methicillin-resistant Staphylococcus aureus (MRSA). The drug works by inhibiting the initiation of bacterial protein synthesis.

Linezolid interactions

Several in vitro models using either human or animal cells have been developed to study the activity of antibiotics against intracellular S. aureus, and a corresponding in vivo model (murine peritonitis) has recently been described and tested with antibiotics, including Linezolid, β-lactams, Gentamicin, Azithromycin, rifampicin, or dicloxacillin5650. [source, 2016]
According to the guideline recommendations, empiric intravenous (IV) Antimicrobial agents for the treatment of suspected severe MRSA ABSSSIs include Vancomycin, Daptomycin, Linezolid, telavancin, or Ceftaroline. [source, 2016]
Patients received either two doses of dalbavancin, 1 g initially followed by 500 mg on day 8 of treatment, or Vancomycin 1 g every 12 hours for ≥3 days, with the option of transitioning to oral Linezolid to Complete 10–14 days of therapy. [source, 2016]
The susceptibilities of the isolates to the clinically relevant antibiotics, Penicillin G, Ampicillin, Ampicillin + sulbactam, Imipenem, Ciprofloxacin, Levofloxacin, teicoplanin, Vancomycin, tigecyclin, cotrimoxazol, Linezolid, Nitrofurantoin, high-level Gentamicin, Erythromycin, Tetracyclin, and trimethoprim/sulfamethoxazol were tested using the VITEK AST-P616 card (bioMérieux Deutschland GmbH, Nürtingen, Germany). [source, 2016]
The resistance of oral E. faecalis isolates to TETRACYCLINE, Erythromycin and high level Gentamicin and of one endodontic isolate against Ciprofloxacin and Linezolid resp. must not be neglected. [source, 2016]
We aim to develop an individualised optimal dosing algorithm that accounts for the relevant effects of RRT modalities and patient clinical characteristics on dosing requirements for Vancomycin, Linezolid, piperacillin-tazobactam and Meropenem. [source, 2016]
This is a multi-national observational PK study designed to analyse PK data using a population PK approach to identify covariates associated with changes in PK parameters for five commonly prescribed antibiotics, Vancomycin, Linezolid, piperacillin/tazobactam and Meropenem in critically ill patients with AKI who are undergoing RRT. [source, 2016]
This comprehensive data set will permit the description of detailed PK data, and allow further analysis of the effect of critical illness, AKI and RRT on the drug disposition of five of the most commonly used antibiotics in ICU patients, namely, Vancomycin, Linezolid, piperacillin/tazobactam and Meropenem. [source, 2016]
However, due to concern about possible toxicity to eukaryotic mitochondria, as observed with many Antibacterial protein synthesis inhibitors such as Linezolid and chloramphenicol2223, we tested the effect of PNA on mitochondrial protein synthesis directly within mammalian cells. [source, 2016]
In-cell ELISA was performed in J774A.1 cells treated with PNA, Ampicillin and Linezolid for three days to detect the levels of mtDNA-encoded COX-I and nDNA-encoded SDH-A proteins. [source, 2016]