Latest research on Lisdexamfetamine

Lisdexamfetamine (L-lysine-d-amphetamine) is a prodrug of the psychostimulant d-amphetamine coupled with the essential amino acid L-lysine. It was developed so that the amphetamine psychostimulant is released and activated more slowly as the prodrug molecule is hydrolyzed consequently cleaving off the amino acid-during the first pass through the intestines and/or the liver. Amphetamines target the trace amine-associated receptor 1 (TAAR1). Amphetamine is also believed to exert its effects by binding to the monoamine transporters (the dopamine transporter or DAT) and increasing extracellular levels of the biogenic amines dopamine, norepinephrine (noradrenaline) and serotonin.

Lisdexamfetamine and alcohol

We used the key search terms alcohol, substance related disorders, death, and combined these with Methylphenidate, Atomoxetine, dexamphetamine and Lisdexamfetamine in turn. [source, 2015]
We included articles which mentioned the coingestion of ADHD medication (Methylphenidate, dexamphetamine, Lisdexamfetamine and Atomoxetine) with another substance including alcohol, publications relating to animal models, and, due to the paucity of data regarding adolescents, all age groups. [source, 2015]