Latest research on Lisdexamfetamine

Lisdexamfetamine (L-lysine-d-amphetamine) is a prodrug of the psychostimulant d-amphetamine coupled with the essential amino acid L-lysine. It was developed so that the amphetamine psychostimulant is released and activated more slowly as the prodrug molecule is hydrolyzed consequently cleaving off the amino acid-during the first pass through the intestines and/or the liver. Amphetamines target the trace amine-associated receptor 1 (TAAR1). Amphetamine is also believed to exert its effects by binding to the monoamine transporters (the dopamine transporter or DAT) and increasing extracellular levels of the biogenic amines dopamine, norepinephrine (noradrenaline) and serotonin.

Lisdexamfetamine side effects

However, whether Lisdexamfetamine treatment might produce an amphetamine-like decrease in cocaine-maintained behaviors remains to be empirically determined. [source, 2015]
Furthermore, we hypothesized that 7 days of Lisdexamfetamine treatment would produce an amphetamine-like decrease in Cocaine choice. [source, 2015]
Test sessions were conducted at 24h, 48h, and 72h after 3.2mg/kg Lisdexamfetamine administration because of the prolonged duration of effects. [source, 2015]
Lisdexamfetamine produced a significant dose-dependent (F3,9 = 24.9, p = 0.0001) and time-dependent (F6,18 = 18.1, p < 0.0001) increase in cocaine-appropriate responses (interaction: F18,54 = 1.8, p = 0.0545). [source, 2015]
Doses of 1.0 and 3.2mg/kg Lisdexamfetamine produced significant cocaine-appropriate responses from 56–300min and 10min to 48h, respectively. d-amphetamine also produced a significant dose-dependent (F3,9 = 39.2, p < 0.0001) and time-dependent (F6,18 = 6.25, p = 0.0011) increase in cocaine-appropriate responses (interaction: F18,54 = 4.2, p < 0.0001). [source, 2015]
Lisdexamfetamine (1.0mg/kg) significantly increased rates of operant responses 56, 100, and 300min post-administration compared to saline (interaction: F18,54 = 2.6, p = 0.0032). [source, 2015]
Both 1.0 and 3.2mg/kg/day Lisdexamfetamine significantly decreased the preference of 0.032mg/kg/injection Cocaine (interaction: F12,46.3 = 4.5, p < 0.0001). [source, 2015]
Mixed-model analyses demonstrated a significant main effect of the Lisdexamfetamine dose on Cocaine choices (F3,8 = 4.4, p = 0.0405); however, post hoc analyses using Dunnett’s test failed to detect any Lisdexamfetamine dose that significantly decreased the number of Cocaine choices earned relative to baseline. [source, 2015]
In summary, 7-day treatments with either Lisdexamfetamine or d-amphetamine significantly decreased Cocaine versus food preference. [source, 2015]
However, in contrast to d-amphetamine, Lisdexamfetamine did not decrease overall rates of response. [source, 2015]