Latest research on Lucentis

Ranibizumab is a recombinant humanized IgG1 kappa isotype monoclonal antibody fragment designed for intraocular use. Ranibizumab binds to and inhibits the biologic activity of human vascular endothelial growth factor A (VEGF-A). Ranibizumab has a molecular weight of approximately 48 kilodaltons and is produced by an E. coli expression system in a nutrient medium containing the antibiotic tetracycline (tetracycline is not detectable in the final product). Ranibizumab is marketed under the name Lucentis®. It is indicated for the treatment of macular edema after retinal vein occlusion, age-related macular degeneration (wet), and diabetic macular edema.

Latest findings

Ranibizumab (Lucentis) is now used in the treatment of age-related macular degeneration and macular edema as an anti-VEGF factor [5, 6], but it remains unclear whether ranibizumab will affect the efficacy of AGV implantation for NVG patients. [source, 2016]
Under topical anesthesia, a needle was introduced through the conjunctival surface 3.8 mm from the corneal limbus in the affected eye for intravitreal injection of 0.5 mg/0.05 mL ranibizumab (Lucentis, 10 mg/mL; Novartis, Basel, Switzerland). [source, 2016]
Leakage on fluorescein angiography improved (Figure 2G) after three monthly intravitreal Lucentis (0.5 mg/0.05 ml, Genentech) injections. [source, 2015]
Neovascular AMD is currently treated with regular intravitreal injections of anti-VEGF agents, including ranibizumab (Lucentis, Genentech, San Francisco, CA), bevacizumab (Avastin, Roche, Basel, Switzerland) and more recently aflibercept (Eylea, Regeneron, Tarrytown, New York). [source, 2015]
The number of anti-VEGF (ranibizumab, trade name Lucentis, Genentech, San Francisco, CA) injections received by each patient prior to blood collection was ascertained from the medical records. [source, 2015]
In most of these studies, researchers evaluated the anesthetic methods in intravitreal injection of ranibizumab (Lucentis, Genentech), bevacizumab (Avastin, Genentech), or triamcinolone (Kenalog, Bristol-Myers Squibb). [source, 2015]
In the randomized Comparison of Age-Related Macular Degeneration Treatments Trials (CATT) that assessed the relative efficacy and safety of ranibizumab (Lucentis, Novartis Pharma, Basel, Switzerland, and Genentech, South San Francisco, Calif. [source, 2015]
Ranibizumab (Lucentis) is a recombinant, humanized anti-VEGF-A antibody fragment derived from Bevacizumab, also approved to treat AMD. [source, 2015]
In 2013, Avastin (bevacizumab) and Lucentis (ranibizumab) were ranked 9th and 19th, respectively, in terms of top global sales of pharmaceutical products emphasising their impact in medicine as a whole [2]. [source, 2015]
Ranibizumab (Lucentis) was determined effective by two pivotal trials: the MARINA (minimally classic/occult trial of the anti-VEGF antibody ranibizumab in the treatment of neovascular AMD) and ANCHOR (anti-VEGF antibody for the treatment of predominantly classic choroidal neovascularisation in AMD) trials. [source, 2015]