Latest research on Lucentis

Ranibizumab is a recombinant humanized IgG1 kappa isotype monoclonal antibody fragment designed for intraocular use. Ranibizumab binds to and inhibits the biologic activity of human vascular endothelial growth factor A (VEGF-A). Ranibizumab has a molecular weight of approximately 48 kilodaltons and is produced by an E. coli expression system in a nutrient medium containing the antibiotic tetracycline (tetracycline is not detectable in the final product). Ranibizumab is marketed under the name Lucentis®. It is indicated for the treatment of macular edema after retinal vein occlusion, age-related macular degeneration (wet), and diabetic macular edema.

Lucentis interactions

In most of these studies, researchers evaluated the anesthetic methods in intravitreal injection of ranibizumab (Lucentis, Genentech), bevacizumab (Avastin, Genentech), or triamcinolone (Kenalog, Bristol-Myers Squibb). [source, 2015]
Neovascular AMD is currently treated with regular intravitreal injections of anti-VEGF agents, including ranibizumab (Lucentis, Genentech, San Francisco, CA), bevacizumab (Avastin, Roche, Basel, Switzerland) and more recently aflibercept (Eylea, Regeneron, Tarrytown, New York). [source, 2015]
Numerous trials (Anti-VEGF Antibody for the Treatment of Predominantly Classic Choroidal Neovascularization in AMD [ANCHOR], Minimally Classic/Occult Trial of the Anti-VEGF Antibody Ranibizumab in the Treatment of Neovascular AMD [MARINA], A Study of Ranibizumab Administered Monthly or on an As-needed Basis in Patients with Subfoveal Neovascular Age-related Macular Degeneration [HARBOR], rhuFab V2 Ocular Treatment Combining the Use of Visudyne to Evaluate Safety [FOCUS], Branch Retinal Vein Occlusion: Evaluation of Efficacy and Safety [BRAVO], Central Retinal Vein Occlusion Study: Evaluation of Efficacy and Safety [CRUISE], Ranibizumab Injection in Subjects with Clinically Significant Macular Edema with Center Involvement Secondary to Diabetes Mellitus [RISE, NCT00473330], Ranibizumab Injection in Subjects with Clinically Significant Macular Edema with Center Involvement Secondary to Diabetes Mellitus [RIDE, NCT00473382]) examining the efficacy and safety of ranibizumab have showed that frequent intravitreal injections reduce the risk of vision loss in patients with CNV and ME.9–25 [source, 2015]
The following terms were used for the searches: (“polypoidal choroidal vasculopathy” OR PCV) AND (“angiogenesis inhibitors” OR “endothelial growth factors” OR VEGF OR Lucentis OR ranibizumab OR bevacizumab OR Avastin) AND (“photodynamic therapy” OR PDT). [source, 2015]
Notable in this context is the failure of pegaptanib to make inroads in the marketplace dominated by therapeutic antibodies, such as bevacizumab (Avastin) or ranibizumab (Lucentis) (44, 45). [source, 2015]
In 2013, Avastin (bevacizumab) and Lucentis (ranibizumab) were ranked 9th and 19th, respectively, in terms of top global sales of pharmaceutical products emphasising their impact in medicine as a whole [2]. [source, 2015]
In response to this, the CATT (Comparison of AMD Treatments Trials) and IVAN (Lucentis and Avastin effective in treating wet AMD) studies aimed to compare the safety and efficacy of using ranibizumab versus bevacizumab [41, 42]. [source, 2015]
Inhibitors of VEGF, such as the monoclonal antibody bevacizumab (Avastin) and antibody derivative ranibizumab (Lucentis), have an evolving therapeutic role in retinopathy by targeting the neovascularization and vascular permeability processes inherent to the disease pathogenesis.27 [source, 2015]
The two VEGF antagonists Lucentis (ranibizumab) and Eylea (aflibercept) have been approved by US Food and Drug Administration to treat the patients with DME. [source, 2015]
Three VEGF inhibitors, SU5416 (Merck KGaA, Darmstadt, Germany), bevacizumab (Avastin, Roche, Basel, Switzerland), and ranibizumab (Lucentis, Novatris, Stein Switzerland) were used as candidate drugs to reverse abnormal retinal neovascularization. [source, 2015]