Latest research on Methicillin

One of the penicillins which is resistant to penicillinase but susceptible to a penicillin-binding protein. It is inactivated by gastric acid so administered by injection. [PubChem]

Latest findings

) were evaluated on the following isolates, obtained from the Department of Medical Microbiology, Ahmadu Bello University Teaching Hospital Zaria, Nigeria (ABUTH): Candida stellatoidea, Candida tropicalis, Candida krusei, Candida albicans, Shigella dysenteriae, Salmonella typhi, Klebsiella pneumonia, Pseudomonas aeruginosa, Proteus vulgaris, Escherichia coli, Corynebacterium ulcerans, Streptococcus pyogenes, Staphylococcus aureus, Vancomycin Resistant Enterococci (VRE), and Methicillin Resistant Staphylococcus aureus (MRSA). [source, 2016]
The synthesised compounds were tested against eleven bacteria including two resistance bacteria, Methicillin Resistant Staphylococcus aureus (MRSA), Vancomycin Resistant Enterococci (VRE), and four fungi. [source, 2016]
The distribution of S. aureus and non-S. aureus Ciprofloxacin susceptibilities as a function of Methicillin susceptibilities in addition to the mecA resistance determinant which is responsible for the Methicillin resistance, is recorded in Table 6. [source, 2016]
A wide dispersion of two categories of resistance has been revealed in the present investigation: 100% of our isolates carried the QRDRs responsible for quinolone resistance genes (gyrA and grlA) (17/27, 63% and 19/27, 70.4%) and the mecA resistance determinant (11/27, 40.7%), responsible for the Methicillin and Oxacillin resistance (Table 5). [source, 2016]
S. aureus, S. haemolyticus, and Enterococcus strains were screened for the presence of mecA (Oxacillin resistance), femA (Methicillin resistance), vanA, and vanB (Vancomycin resistance) genes using respective primers (Table 1) as described in previous studies (Arakere et al., 2005; Jia et al., 2014). [source, 2016]
Generally, our results are in assonance with Chajęcka-Wierzchowska et al. (2015) who displayed that, all Methicillin resistant staphylococci harbored mecA gene but in consonance with the investigation outcomes of Martineau et al. (2000), Lee et al. (2004), and Guran and Kahya (2015), who indicated the occurrence of staphylococci strains resistant to Methicillin or/and Oxacillin in the absence of the mecA gene. [source, 2016]
71.4% of Enterococcus spp. were resistant to Vancomycin whereas all the Staphylococcus spp. were resistant to Methicillin. [source, 2016]
The most important outcome of our investigation was the alarming finding that, most of the MRSA and NSA-MR isolated from retail meat in the Egyptian market were >50% resistant to clinically important antimicrobials (sulfamethoxazole/trimethoprim, Clindamycin, gentamycin, peniciilin, Oxacillin, Vancomycin, TETRACYCLINE, Methicillin, Ciprofloxacin, and Erythromycin in descending order) imposing a severe threat to public health of the Egyptians. [source, 2016]
Consistent with these results, Kaplan et al. showed that an agr mutation did not affect the amount of biofilm induction caused by low-level Methicillin in S. aureus [17]. [source, 2016]
Distribution of various β-lactamases and Methicillin, and Vancomycin resistance genes in different isolates is presented in Table 4. [source, 2016]