Latest research on Metoclopramide

A dopamine D2 antagonist that is used as an antiemetic. [PubChem]

Latest findings

In the clinic, when Metoclopramide poorly controls vomiting, a low-dose oral hormone can be added to increase patient appetite and alleviate adverse reactions. [source, 2016]
Anesthesia and tumor manipulation are the most well-known triggers for catecholaminergic crisis; positional change, exercise, and various medications (e.g. TCAs, opiates, Metoclopramide and radiographic contrast agents) are other possible precipitating factors. [source, 2016]
Phenothiazines (eg, Phenergan) and Dopamine antagonists (eg, Metoclopramide) may be used as second-line treatments, followed by 5-hydroxytryptamine-3 receptor antagonists (eg, Ondansetron). [source, 2016]
Tables 1 and 2 illustrate the variations in HG-defining characteristics and outcome measures in eight clinical trials investigating the effectiveness of Metoclopramide and Promethazine. [source, 2016]
Pharmaceutical treatments include anticholinergics, antihistamines, Dopamine antagonists, vitamins (B6 and B12), H3 antagonists [1], corticosteroids and Metoclopramide. [source, 2016]
Incidence and severity of PONV (see Table 3) were noted and if PONV score was >2, IV Metoclopramide 150 mcg/kg was administered. [source, 2016]
Statistical comparisons between Metoclopramide administration and the baseline period were performed used a Wilcoxon signed rank test. [source, 2016]
Consistent with previous reports, mean resting LES pressure in a supine position was significantly elevated after intravenous administration of Metoclopramide (13.7 ± 9.2 vs 26.7 ± 8.8 mmHg, P < 0.05). [source, 2016]
In addition, Metoclopramide significantly augmented maximal peristaltic contractions, especially in segment 3 (distal; 109.8 ± 45.4 vs 140.5 ± 51.7 mmHg, P < 0.05) (Fig. 1 and Table 1). [source, 2016]
On the other hand, Metoclopramide did not change EGJ compliance after intravenous administration. [source, 2016]