Latest research on Mitoxantrone

An anthracenedione-derived antineoplastic agent. [PubChem]

Latest findings

These orphan drugs are Imiglucerase, sapropterin dihydrochloride, recombinant coagulation Factor VIII, coagulation factor VIIa, human coagulation Factor VIII, human prothrombin complex concentrate, bosentan, Iloprost, ambrisentan, recombinant human Growth hormone, Busulfan, teniposide, Mitoxantrone, Imatinib, Dasatinib, nilotinib, meisoindigo, Arsenious Acid, homoharringtonine, rituximab, sorafenib, Danazol, Riluzole and poractant alfa. [source, 2016]
There is still no curative treatment, but during the last 20 years eight different therapies have become available including interferon beta, glatiramer acetate, teriflunomide, dimethyl fumarate, natalizumab, fingolimod, alemtuzumab and Mitoxantrone, and several new compounds are in development. [source, 2016]
This treatment regime has been used with success for patients with aggressive RRMS, using Mitoxantrone 61. [source, 2016]
The use of Mitoxantrone is declining because of its long-term safety profile. [source, 2016]
Prior immunosuppressant therapies that were most commonly given to 68 patients who developed natalizumab-related PML included (some patients received more than one agent): Mitoxantrone (38/68 (55.9%) confirmed PML cases), Cyclophosphamide (14/68 (20.6%) confirmed PML cases), Azathioprine (11/68 (16.2%) confirmed PML cases), methotrexate (9/68 (13.2%) confirmed PML cases), Mycophenolate mofetil (6/68 (8.8%) confirmed PML cases), and other immunosuppressants (8/68 (11.8%) confirmed PML cases). [source, 2016]
All patients with non-M3 AML received intensive induction therapy with Daunorubicin and Cytarabine or Mitoxantrone and Cytarabine or Decitabine (demethylating treatment) followed by consolidation therapy with Cytarabine-based therapy. [source, 2016]
Besides Methylprednisolone, a corticosteroid used immediately after the diagnosis of MS and before any other more specific therapeutic approaches, FDA has approved seven other DMTs which are already in commerce: Interferon-β-1a (IFN-β-1a), IFN-β-1b, Glatiramer acetate, Mitoxantrone, Teriflunomide, Fingolimod, and Natalizumab [16]. [source, 2016]
It has been shown, indeed, that Nrf2 silencing attenuates the expression of the ABCG2 transcript and protein and sensitises lung cancer cells to Mitoxantrone and Topotecan, two representative chemotherapeutic drugs effluxed mainly by the presence of ABCG2 [92]. [source, 2016]
As previously described [15], the cumulative isotoxic anthracycline dose was calculated as the sum of the following: Doxorubicin + (Daunorubicin × 0.833) + (Epirubicin × 0.57) + (Idarubicin × 5) + (Mitoxantrone × 4). [source, 2016]
Neoadjuvant chemotherapy consisted of Vinblastine, Doxorubicin and Mitoxantrone in one patient, while in two patients more than three cytostatic drugs were used (Vinblastine, Doxorubicin, Docetaxel and Cisplatin in one patient; Vinblastine, Cisplatin, Doxorubicin, Bleomycin, Cyclophosphamide, Mitoxantrone in another one). [source, 2016]