Latest research on Mycophenolate

Mycophenolic acid is an an immunosuppresant drug and potent anti-proliferative, and can be used in place of the older anti-proliferative azathioprine. It is usually used as part of triple therapy including a calcineurin inhibitor (ciclosporin or tacrolimus) and prednisolone. It is also useful in research for the selection of animal cells that express the E. coli gene coding for XGPRT (xanthine guanine phosphoribosyltransferase).

Latest findings

There is an ongoing debate over the efficacy and safety of immunosuppressive agents other than glucocorticoid monotherapy in patients with IgAN who present with moderate to severe proteinuria; specifically, the use of relatively novel agents, including Leflunomide (LET) and Mycophenolate mofetil (MMF). [source, 2016]
Mycophenolate mofetil (MMF), Wysolone, and Tacrolimus were used in patients both with and without cryptosporidiosis (17/43, 39.5% versus 30/80, 37.5%; P = 0.85). [source, 2016]
The combination of Mycophenolate mofetil (MMF), Wysolone, and Tacrolimus drugs was mostly used in both patient and control groups. [source, 2016]
All patients received immunosuppressants that include Tacrolimus, low‐dose steroid, and Mycophenolate mofetil as standard immunosuppressant regimen. [source, 2016]
Expert clinicians anecdotally believe that systemic treatments with the greatest success rates are hydroxychloroquine, methotrexate, Mycophenolate mofetil and Prednisolone. [source, 2016]
The objectives of the ‘hELP’ study are to administer, for a 6-month period, in patients with ELPV that has been refractory to first-line therapy, Clobetasol Propionate 0.05 % topically plus adjuvant systemic therapy with hydroxychloroquine, methotrexate or Mycophenolate mofetil, and compare against topically administered Clobetasol Propionate 0.05 % with adjuvant Prednisolone given orally. [source, 2016]
He had a history of radiation therapy for acne as a child, as well as chronic sun exposure, and was chronically immunosuppressed secondary to the use of Mycophenolic Acid (Cellcept) for myasthenia gravis. [source, 2016]
Prior immunosuppressant therapies that were most commonly given to 68 patients who developed natalizumab-related PML included (some patients received more than one agent): Mitoxantrone (38/68 (55.9%) confirmed PML cases), Cyclophosphamide (14/68 (20.6%) confirmed PML cases), Azathioprine (11/68 (16.2%) confirmed PML cases), methotrexate (9/68 (13.2%) confirmed PML cases), Mycophenolate mofetil (6/68 (8.8%) confirmed PML cases), and other immunosuppressants (8/68 (11.8%) confirmed PML cases). [source, 2016]
The favorable safety profile of CMVIG as compared with Ganciclovir derivatives and other antiviral agents permits its administration as rescue or adjunctive therapy: in patients with leucopenia (a common side effect of Ganciclovir), especially those receiving Mycophenolic Acid immunosuppression; in patients who are intolerant to antiviral agents; or in those who are under intense immunosuppression (eg, antirejection treatment with high-dose steroids or lymphocyte-depleting therapy). [source, 2016]
She was under antihypertensive therapy and immunosuppressant drugs (Prednisolone, Mycophenolate, and Cyclosporine). [source, 2016]