Latest research on Nexium

A highly effective inhibitor of gastric acid secretion used in the therapy of stomach ulcers and zollinger-ellison syndrome. The drug inhibits the H(+)-K(+)-ATPase (H(+)-K(+)-exchanging ATPase) in the proton pump of gastric parietal cells. [PubChem]

Latest findings

Nexium (esomeprazole) prescribed for suggested gastric acid reflux, made me worse. [source, 2009]
The only medications patient was taking at the time of the event were Nexium 40 mg per day and Posture D vitamins. [source, 2009]
A total of 608 and 556 chronic NSAID users, respectively, were randomized to treatment in the two identical Nexium Anti-Inflammatory Symptom Amelioration (NASA1) and Symptoms Prevention by Acid Control with Esomeprazole (SPACE1) protocols. [source, 2009]
The acute 4-week symptom relief studies (Nexium Anti-inflammatory Symptom Amelioration [NASA1] and Symptom Prevention by Acid Control with Esomeprazole [SPACE1] studies) have shown that esomeprazole (20 and 40 mg) relieves upper GI symptoms in patients using NSAIDs, including selective COX-2 inhibitors [12]. [source, 2007]
AE = adverse event; COX-2 = cyclo-oxygenase-2; GERD = gastroesophageal reflux disease; GI = gastrointestinal; GSRS = Gastrointestinal Symptom Rating Scale; HRQL = health-related quality of life; NASA = Nexium Anti-inflammatory Symptom Amelioration; NSAID = non-steroidal anti-inflammatory drug; PPI = proton pump inhibitor; QOLRAD = Quality of Life in Reflux and Dyspepsia; SPACE = Symptom Prevention by Acid Control with Esomeprazole. [source, 2007]
The industry standard in this type of strategy was set by AstraZeneca which successfully launched Nexium when Losec/Prolosec was about to lose patent protection. [source, 2007]
Nexium 'has been found to be pretty much identical to Prilosec and about ten times more expensive' [[5], p. [source, 2007]
The drugs granted pediatric exclusivity include 5 out of the “Top 10” prescription drugs with the highest sales figures in North America in 2005: atorvastatin (Lipitor), simvastatin (Zocor), Omeprazole (Nexium), lansoprazol (Prevacid), and sertraline (Zoloft). [source, 2007]