A highly effective inhibitor of gastric acid secretion used in the therapy of stomach ulcers and zollinger-ellison syndrome. The drug inhibits the H(+)-K(+)-ATPase (H(+)-K(+)-exchanging ATPase) in the proton pump of gastric parietal cells. [PubChem]
Notably, in one study, it was reported that the majority of patients with long-segment BE who received different dosages of esomeprazole (Nexium), a second-generation PPI, had an intra-gastric pH >4 for 81–88% of the day (the higher the dosage the longer the duration) (26).
The toxicity profile of esomeprazole strontium was comparable to that of Esomeprazole Magnesium in a preclinical study, and no developmental toxicity was observed in a dose-ascending study examining its effects on embryo–fetal development.11
After discussion with their treating psychiatrist, two patients who had required intensive potassium repletion (including via ICU and PIC lines) were commenced on a low dose of Nexium as outpatients.
Neither patient required intravenous potassium, although levels did fall intermittently (when patients omitted doses of Nexium).
He received three treatments of chemoembolization, Octreotide, and high doses of Nexium at that facility.