A highly effective inhibitor of gastric acid secretion used in the therapy of stomach ulcers and zollinger-ellison syndrome. The drug inhibits the H(+)-K(+)-ATPase (H(+)-K(+)-exchanging ATPase) in the proton pump of gastric parietal cells. [PubChem]
The toxicity profile of esomeprazole strontium was comparable to that of Esomeprazole Magnesium in a preclinical study, and no developmental toxicity was observed in a dose-ascending study examining its effects on embryo–fetal development.11
As a result, Esomeprazole Strontium is expected to be used as an osteoarthritis treatment to improve patient compliance and to enable the effective management of GI symptoms.
A good example is the consumer advertising of “the purple pill,” Nexium, while generic Prilosec, equally effective in almost all patients, is not advertised.