Latest research on Niacin

A water-soluble vitamin of the B complex occurring in various animal and plant tissues. It is required by the body for the formation of coenzymes NAD and NADP. It has pellagra-curative, vasodilating, and antilipemic properties. [PubChem]

Latest findings

Vitamin a stock was 20 mg Thiamine (Sigma, T1270), 100 mg Riboflavin (Sigma, R4500), 120 mg Nicotinic Acid (Sigma, N0761), 160 mg D-pantothenic acid hemicalcium salt (Sigma, P5155), 25 mg Pyridoxine (Sigma, P6280) and 2 mg Biotin (Sigma, B4501), dissolved in 1 L deionized water, aliquoted and frozen at -20°C protected from light. [source, 2016]
The first pathway was the RNA polymerase glycolysis/gluconeogenesis; the second was the fatty acid elongation in mitochondria and polyketide sugar unit biosynthesis; and the fifth pathway was the biosynthesis of alkaloids derived from ornithine lysine and Nicotinic Acid, Glycine serine and Threonine metabolism, Alanine aspartate and glutamate metabolism, Valine Leucine and isoLeucine biosynthesis, and sphingolipid metabolism. [source, 2016]
It is suggested that dietary Nicotinic Acid (NA) could act as an alternative anti-lipolytic agent. [source, 2016]
Two groups of them were fed diets with NA supplementation (NA) (> 99.5% Nicotinic Acid, not rumen-protected, Lonza Ltd. [source, 2016]
Although the high concentration of purified polysaccharide, PSG-1, showed noticeable antioxidant ability, it was much lower than the crude polysaccharide, probably attributing to other constituents contained in crude polysaccharides extracts, such as proteins, amino acids, peptides, cellulose, phytosterol, Ascorbic Acid, Thiamine, nucleotide, Nicotinic Acid, organic acids, and microelements [71]. [source, 2016]
, Nicotinic Acid ADENINE dinucleotide phosphate (NAADP; EC50 ∼0.73 mmol/L) [source, 2016]
Pharmaceutical interventions developed for the management of hypertiglyceridemia have been also shown to inhibit triglyceride biosynthesis in HepG2 cells and Niacin was reported to reduce the incorporation of [14C]-acetate into triglycerides by 20–40% in HepG2 cells [81]. [source, 2016]
Today, HDL therapies that lower cardiovascular risk are not yet available [82] and multiple drug classes (fibrates, Niacin, statins) induce modest increases in HDL cholesterol concentration. [source, 2016]
Differences in the relative abundance of 3 metabolites; dodecanoic acid (77%), myristic acid (101%), and Nicotinic Acid (21%), remained significant after FDR adjustment for multiple testing (Fig. 1). [source, 2016]
After correction for multiple testing, pyroglutamic acid and PHENYLALANINE were found to be significantly more abundant in the OVT73 cerebellum, and dodecanoic acid, myristic acid and Nicotinic Acid were significantly more abundant in the OVT73 liver. [source, 2016]