Octreotide is the acetate salt of a cyclic octapeptide. It is a long-acting octapeptide with pharmacologic properties mimicking those of the natural hormone somatostatin.
Octreotide and alcohol
Moreover, other recent techniques for the management of insulinoma have been reported, including injection of Octreotide, EUS guided alcohol ablation, radiofrequency ablation, or embolization of an insulinoma .
Data was collected on demographic and clinical variables including age, gender, race, alcohol use, tobacco use, etiology of cirrhosis/portal hypertension, infection with hepatitis B or hepatitis C, use of proton pump inhibitors (PPIs), use of Octreotide, use of antibiotics, and etiology of gastric varices.
Plentz et al. recruited 41 patients with advanced HCC and cirrhosis, including predominantly alcoholic, and HBV and HCV-induced secondarily cirrhosis, treated with short-acting and long-acting Octreotide.
In the first case, the platelet count in a 53-year-old man with alcohol-induced cirrhosis dropped immediately after Octreotide administration from 144,000/mm3 to 75,000/mm3 and continued to decrease within the next 50 hours to 4000 despite multiple platelet transfusions.
In the second reported case, that of a 42-year-old woman with hepatitis C- and alcohol-induced cirrhosis, the patient's platelet count dropped immediately from 122,000/mm3 to 72,000/mm3 following Octreotide administration .
Progesterone, fatty meal, chocolate, alcohol, peppermint, Theophylline, Octreotide, anticholiergics, etc. are known to decrease the LES tone.