Latest research on Octreotide

Octreotide is the acetate salt of a cyclic octapeptide. It is a long-acting octapeptide with pharmacologic properties mimicking those of the natural hormone somatostatin.

Octreotide indications

BCI had a strong prognostic effect on RFS in patients with early-stage breast cancer treated with Tamoxifen alone or with Tamoxifen and Octreotide. [source, 2016]
The effectiveness of the Octreotide on the diarrhea made the diagnosis of a VIPoma highly likely. [source, 2016]
Prednisone and Indomethacin are also considered to be effective in alleviating the clinical symptoms; therefore, Octreotide, at a dosage of 100 mg daily, combined with 20 mg Prednisone daily were administered to the patient in this study to control the symptom of diarrhea and arrest the liver metastasis. [source, 2016]
The combined application of corticosteroids with Octreotide may reduce the required dosage of Octreotide, avoid the side-effects and ease the financial burden of the patient. [source, 2016]
Test day 2: to identify the isolated effect of Glucagon, an infusion of somatostatin (Octreotide, Hospira Nordic AB, Stockholm, Sweden) at 100 ng/kg/min was started 10 min prior to the Glucagon infusion and was infused for additional 2 h. [source, 2015]
Prior reports indicate that use of Octreotide, a potent inhibitor of gastrointestinal hormones including gastrin, motilin, secretin, and pancreatic polypeptide, is also safe and effective (5) (6) (7). [source, 2015]
For instance, it has been reported that Octreotide injection stimulates MMC-like activity in scleroderma patients and reduces some of their symptoms (61), and other drugs have shown promising effects on intestinal motility (62, 63). [source, 2015]
Octreotide, a somatostatin analog, was reported to reduce both hyperinsulinemia and BMI in a double-blind placebo-controlled study; however, it supports weight stability only in patients with profound hyperinsulinemia and is limited by significant side effects [29]. [source, 2015]
Octreotide potentiates the effects of Midodrine by decreasing secretion of Glucagon, which plays a role in splanchnic vasodilation. [source, 2015]
To this end, primary cell cultures were obtained from 3-week-old GC tumors and the effect of the somatostatin analogues SOM-230 (multireceptor ligand), Octreotide (higher affinity to Sstr2) and BIM-23120 (Sstr2 specific) on GH secretion and cell proliferation was measured. [source, 2015]