Latest research on Omeprazole

A highly effective inhibitor of gastric acid secretion used in the therapy of stomach ulcers and Zollinger-Ellison syndrome. Omeprazole belongs to a class of antisecretory compounds, the substituted benzimidazoles, that suppress gastric acid secretion by specific inhibition of the H+/K+ ATPase enzyme system at the secretory surface of the gastric parietal cell.

Latest findings

The most commonly used regimen is triple therapy: a proton pump inhibitor (Omeprazole)71 in association with Amoxicillin and CLARITHROMYCIN. [source, 2016]
For failure of the first line therapy or for clarithromycin-resistant isolated strains, it is available a bismuth-based quadruple therapy with Omeprazole, bismuth salts, Metronidazole and TETRACYCLINE (OBMT),74 an RCT using a combination of PPI and a single three-in-one capsule tablet showed improved eradication in comparison with standard triple therapy. [source, 2016]
Over the past 3 months, he had failed treatment with inhaled fluticasone/salmeterol, fluticasone Nasal spray, Omeprazole, Loratadine as well as a short course of oral Prednisone. [source, 2016]
Neither has evidence of airflow obstruction (normal FEF25-75, with FEV1 at 90% and 79% for the older and younger sibling, respectively) and both are clinically stable with regular chest physiotherapy, Azithromycin Antibiotic prophylaxis and acid suppression with Omeprazole. [source, 2016]
After the injection, the dogs were sent home and the owners given instructions on the administration of cephalosporin (20 mg/kg/12h, PO) and Omeprazole (0.7 mg/kg/24h, PO) as a prophylactic Antibiotic and gastric Mucosa protector, respectively, for 7 days. [source, 2016]
In 2006, a study by Gilard et al. raised concerns about a possible drug-drug interaction between Clopidogrel and Omeprazole (a PPI) that could result in a decreased efficacy of Clopidogrel when taken in combination with Omeprazole [6]. [source, 2016]
Clopidogrel is a pro-drug that is metabolically activated by the cytochrome p450 2C19 (CYP2C19); Omeprazole (and its enantiomer, esOmeprazole) is also metabolized through the same liver enzyme. [source, 2016]
In contrast to these studies, Gilard et al. published another study in 2008, concluding that, based on 124 patients enrolled in a double-blind placebo-controlled trial, Omeprazole had a significant inhibitory effect on Clopidogrel, as assessed by vasodilator-stimulated phosphoprotein phosphorylation test [9]. [source, 2016]
Other studies attempted to show whether the patients’ genetic backgrounds had an impact on the metabolism of Clopidogrel and Omeprazole, but these also yielded mixed conclusions [10,11]. [source, 2016]
By November 2009, based on new findings from further studies performed by Clopidogrel manufacturers, the FDA issued a Safety Communication stating that Omeprazole reduced the antithrombotic effect of Clopidogrel by almost half when taken concomitantly, and that concomitant use should be avoided [1,13]. [source, 2016]