Latest research on Oxcarbazepine

Oxcarbazepine is structurally a derivative of carbamazepine, adding an extra oxygen atom to the benzylcarboxamide group. This difference helps reduce the impact on the liver of metabolizing the drug, and also prevents the serious forms of anemia occasionally associated with carbamazepine. Aside from this reduction in side effects, it is thought to have the same mechanism as carbamazepine - sodium channel inhibition - and is generally used to treat partial seizures in epileptic children and adults.

Latest findings

Finally, it is noteworthy to mention that the antiepileptic drugs (AED) carbamazepine (CBZ), Oxcarbazepine (OXC), and eslicarbazepine (ESL) may themselves represent a cause of hyponatremia due to syndrome of inappropriate Antidiuretic hormone. [source, 2016]
In his medical history he had arterial hypertension, diabetes mellitus and past episodes of seizures in treatment with Oxcarbazepine. [source, 2015]
Furthermore, the calculated PI for Divalproex and Oxcarbazepine should be interpreted with extreme caution because pivotal trials did not evidence superiority over placebo (Bowden et al., 2000; Vieta, Cruz, et al., 2008). [source, 2015]
Moreover, work by Hu et al. [35] (albeit their patients suffered mild cutaneous reactions) indicates that patients with HLA-B*1502 should also avoid newer anticonvulsants such as Oxcarbazepine. [source, 2015]
Conversely, when our controls tolerated CBZ, they also tolerated other anticonvulsants such as Phenytoin, Phenobarbital, Oxcarbazepine and sodium Valproate. [source, 2015]
To reduce the mortality and morbidity associated with these severe drug-induced reactions we propose that Vietnamese patients, here or overseas, have their HLA genotype determined, prior to the planned commencement of any of the aromatic anticonvulsants and if they are found to possess HLA-B*1502, they should not be treated with CBZ, Phenytoin, Phenobarbital or Oxcarbazepine or any aromatic anticonvulsants developed in the future. [source, 2015]
Both Oxcarbazepine and Levetiracetam were trialed separately for treatment of the seizures, with no significant improvement noted. [source, 2015]
Over several decades, there has been increased interest in the treatment of bipolar disorder by using medications such as carbamazepine and Oxcarbazepine, which are the established antiepileptic agents as well as new generation antiepileptics such as Lamotrigine and Topiramate along with certain most widely used antidepressants were known to exhibit calcium-channel-blocking properties that are relevant to the pathophysiology of epilepsies. [source, 2015]
Another peculiarity of ESL has been reported by an experimental study which showed that this drug could reduce VGSC availability through enhancement of slow inactivation, as reported for lacosamide, while it seems not able to alter fast inactivation of VGSC, unlike carbamazepine (CBZ) and Oxcarbazepine (OXC) [6]. [source, 2015]
In terms of efficacy Oxcarbazepine is assumed to be comparable to CBZ but with a more favorable risk profile. [source, 2015]