Latest research on Oxybutynin

Oxybutynin is an anticholinergic medication used to relieve urinary and bladder difficulties, including frequent urination and inability to control urination, by decreasing muscle spasms of the bladder. It competitively antagonizes the M1, M2, and M3 subtypes of the muscarinic acetylcholine receptor.

Latest findings

He had urologic history including left orchiectomy and left groin radiation many years ago, benign prostatic hyperplasia (BPH) treated with transurethral resection of the prostate (TURP) twice, overactive bladder treated with Oxybutynin, low testosterone treated with transdermal testosterone replacement, recurrent prostatitis, and irritative voiding symptoms. [source, 2015]
Various antimuscarinics, such as Oxybutynin, propiverine, Tolterodine, Trospium Chloride, Fesoterodine, and solifenacin were used in the treatment of OAB, and they have been widely used with their proven effectiveness and stability. [source, 2015]
In a study that compared solifenacin and Oxybutynin, solifenacin has been found to be very effective in terms of OAB symptoms. [source, 2015]
For instance, Chiba et al39 demonstrated that the addition of 1.0% HPC effectively prolonged Oxybutynin retention in the bladder compared to intravesical instillation of its solution. [source, 2015]
Her home medications included Lisinopril, Metformin, Oxybutynin, Aspirin, and Omeprazole. [source, 2015]
For example, Oxybutynin is the most widely prescribed antimuscarinic for OAB. [source, 2015]
Oxybutynin is a tertiary amine, and when administered orally, undergoes extensive upper gastrointestinal and first-pass hepatic metabolism via the cytochrome P450 system. [source, 2015]
Intravesical administration of Oxybutynin compared to oral showed higher bioavailability, with reduced concentration of its active metabolite N-DEO.33 [source, 2015]
Oxybutynin is mainly metabolized by P450-bound microsomal enzyme system in liver [13]. [source, 2015]
The cytochromosomal enzyme family responsible for the oxidation, reduction, and peroxidation of both Oxybutynin and propiverine is CYP3A4 [13–15]. [source, 2015]