Latest research on Oxycodone

Semisynthetic derivative of codeine that acts as a narcotic analgesic more potent and addicting than codeine. [PubChem]

Oxycodone dosage

Oxycodone has no capping dose due to the absence of a “ceiling” effect. [source, 2016]
However, the Oxycodone dosage is restricted for various reasons in clinical practice. [source, 2016]
This article reports the use of high-dose OxyContin to treat a patient who was admitted to our hospital, with the aim of providing a reference for the clinical application of Oxycodone. [source, 2016]
The time of the first Oxycontin dose was used as the baseline in this report. [source, 2016]
At the end stage of the disease, the Analgesic effect of Oxycontin at 600 mg Q12h did not last for 12 hours, and the patient refused to take additional dose increments at each drug administration. [source, 2016]
Therefore, oral administration of 600 mg Oxycontin Q8h was attempted, and the daily dose reached 1,800 mg. [source, 2016]
When the daily dose of Oxycontin reached 1,800 mg, which is equivalent to 2,400 mg of Morphine, the patient did not exhibit respiratory depression or other mental symptoms that are usually caused by Morphine, such as drowsiness, euphoria, and cognitive changes. [source, 2016]
Although data from this patient indicate that high-dose Oxycontin is safe, we are unsure whether this dose can be utilized in other patients; even at a lower dose, this drug may cause serious, even life-threatening, adverse reactions in other patients. [source, 2016]
Moreover, we cannot determine the highest clinical dose of Oxycontin based on a few cases because we cannot blindly pursue the goal of completely eradicating pain while ignoring potential concerns regarding side effects, which may have terrible consequences. [source, 2016]
The intended Analgesic effect was achieved by adjusting the Oxycontin dose. [source, 2016]