Latest research on Oxycodone

Semisynthetic derivative of codeine that acts as a narcotic analgesic more potent and addicting than codeine. [PubChem]

Oxycodone indications

Oxycodone has no capping dose due to the absence of a “ceiling” effect. [source, 2016]
At the end stage of the disease, the Analgesic effect of Oxycontin at 600 mg Q12h did not last for 12 hours, and the patient refused to take additional dose increments at each drug administration. [source, 2016]
Moreover, we cannot determine the highest clinical dose of Oxycontin based on a few cases because we cannot blindly pursue the goal of completely eradicating pain while ignoring potential concerns regarding side effects, which may have terrible consequences. [source, 2016]
The intended Analgesic effect was achieved by adjusting the Oxycontin dose. [source, 2016]
Narcotic drugs including Oxycodone, codeine, Propoxyphene, Hydrocodone, and Morphine have classically been utilized for the effective treatment of pain following craniotomies. [source, 2016]
At the same plasma concentration, Oxycodone has a more powerful effect than Morphine, which indicates that Oxycodone has stronger Analgesic effect on the central nervous system, because of its higher concentration in cerebrospinal fluid. [source, 2015]
So far, the present study is the first clinical trial associated with the effect of preemptive intravenous Oxycodone on spinal anesthesia and the postoperative Tramadol analgesia in patients undergoing TURP. [source, 2015]
Therefore, studies with a larger sample need to be carried out to evaluate the effect of preemptive Oxycodone on the quality of spinal analgesia. [source, 2015]
In conclusion, the results indicate that preoperative intravenous Oxycodone could reduce postoperative pain and postoperative analgesia, without worsening instability in blood circulation, affecting motor block, or increasing any of the adverse effects. [source, 2015]
Both figures confirmed all Analgesic combinations were better than the placebo, and showed Ibuprofen 400mg with Oxycodone 5mg offered the highest Analgesic effect after lower third molar surgery. [source, 2015]