Latest research on Oxycodone

Semisynthetic derivative of codeine that acts as a narcotic analgesic more potent and addicting than codeine. [PubChem]

Oxycodone side effects

When the daily dose of Oxycontin reached 1,800 mg, which is equivalent to 2,400 mg of Morphine, the patient did not exhibit respiratory depression or other mental symptoms that are usually caused by Morphine, such as drowsiness, euphoria, and cognitive changes. [source, 2016]
Although data from this patient indicate that high-dose Oxycontin is safe, we are unsure whether this dose can be utilized in other patients; even at a lower dose, this drug may cause serious, even life-threatening, adverse reactions in other patients. [source, 2016]
Moreover, we cannot determine the highest clinical dose of Oxycontin based on a few cases because we cannot blindly pursue the goal of completely eradicating pain while ignoring potential concerns regarding side effects, which may have terrible consequences. [source, 2016]
At the same plasma concentration, Oxycodone has a more powerful effect than Morphine, which indicates that Oxycodone has stronger Analgesic effect on the central nervous system, because of its higher concentration in cerebrospinal fluid. [source, 2015]
The other adverse effects were related to the side effect of the opioid Oxycodone HCL but the prevalences were low (0.4–2.4%). [source, 2015]
Unlike the moderate increase in Morphine consumption (+0.01 DDD/1,000/day), Oxycodone consumption increased from 0.01 DDD/1,000/day in 2007 to 0.05 DDD/1,000/day by the end of the study (Table 1). [source, 2015]
Consumption of Oxycodone, Fentanyl, and methadone in that 5-year period was increased. [source, 2015]
Consumption of opioids was increasing in Canada up till the year 2011, when due to decreased consumption of Oxycodone consumption of all opioids was decreased. [source, 2015]
Thebaine is a precursor to codeine and Morphine biosynthesis in planta (Fig 1) and is also the starting precursor for the chemical synthesis of the analgesics Oxycodone and buprenorphine, which have more favourable side-effect profiles than Morphine [1,2]. [source, 2015]
The use of Oxycodone in the US increased by 866 % from 1997 to 2007 and accounted for almost half of total opioids dispensed in 2008 [2, 3]. [source, 2015]