Latest research on Phendimetrazine

Phendimetrazine is a weight loss medication. Phendimetrazine is chemically related to amphetamines and is a Schedule III drug under the Convention on Psychotropic Substances. In the United States, phendimetrazine is a Schedule III controlled substance under the Uniform Controlled Substances Act of 1970.

Latest findings

In contrast to Lisdexamfetamine, the prodrug Phendimetrazine displayed a clockwise hysteresis loop (data reanalyzed from Banks et al., 2013c), which suggests that Phendimetrazine is an active parent drug for an active metabolite. [source, 2015]
Overall, these differential hysteresis effects between the prodrugs Lisdexamfetamine and Phendimetrazine are consistent with the differential onsets of cocaine-appropriate responses produced by these two compounds in the cocaine discrimination procedure. [source, 2015]
Said another way, the cocaine-like discriminative stimulus effects of Lisdexamfetamine are mediated exclusively by the conversion of Lisdexamfetamine to d-amphetamine; in contrast, both the parent drug Phendimetrazine and the active metabolite phenmetrazine contribute to the cocaine-like effects of Phendimetrazine. [source, 2015]
To date, two prodrugs have been examined as candidate pharmacotherapies in preclinical models of Cocaine addiction: Phendimetrazine (Banks et al., 2013b, 2013d) and Lisdexamfetamine (present study). [source, 2015]
Moreover, data discussed here suggest that Lisdexamfetamine may be preferable to Phendimetrazine because of its counter-clockwise hysteresis plot, suggestive of activity for only the metabolite and not the parent drug. [source, 2015]
Phendimetrazine is currently being evaluated in a human laboratory safety study as a potential pharmacotherapy for Cocaine addiction (NCT02233647). [source, 2015]
These clinical studies will provide important new data to assess both: (A) the clinical utility of Phendimetrazine and Lisdexamfetamine as candidate pharmacotherapies; and (B) the predictive validity of preclinical drug versus food choice procedures as tools to study candidate pharmacotherapies. [source, 2015]
For comparison, a similar graph was generated from previously published data relating %CAR to plasma phenmetrazine levels after administration of 3.2mg/kg Phendimetrazine, which is a prodrug for phenmetrazine (Banks et al., 2013c). [source, 2015]
For comparison, we also generated a hysteresis loop (Figure 2B) for Phendimetrazine, a phenmetrazine prodrug, from previously published data (Banks et al., 2013c). [source, 2015]
So far, American FDA approved only 4 short-time use drugs as phentermine, Diethylpropion, Phendimetrazine, and Benzphetamine and 3 medium- and long-time use ones as orlistat, lorcaserin, and phentermine plus topiramate-ER. [source, 2015]