Latest research on Physostigmine

A cholinesterase inhibitor that is rapidly absorbed through membranes. It can be applied topically to the conjunctiva. It also can cross the blood-brain barrier and is used when central nervous system effects are desired, as in the treatment of severe anticholinergic toxicity. [PubChem]

Latest findings

To verify the accuracy of the employed docking methods, we first selected four known inhibitors for these enzymes (Physostigmine, Indinavir, epalrestat and Celecoxib, Fig. 1) as reference molecules. [source, 2016]
For instance, some authors administered an acetylcholinesterase inhibitor – Physostigmine – to individuals diagnosed with borderline personality disorder, other personality disorders, and healthy controls (69). [source, 2016]
Those individuals diagnosed with a personality disorder who displayed a depressive response to the Physostigmine challenge were more likely to present a sense of emptiness. [source, 2016]
Fast blue B salt was obtained from the Shanghai Equilibrated Reagent Factory (Shanghai, China); Physostigmine was ordered from Fluka (Buchs, Switzerland); Coomassie blue G-250 was acquired from Amresco Co. (Solon, USA); bovine serum albumin (BSA) was obtained from Shanghai BioLife Science & Technology Co. (Shanghai, China); Sodium dodecyl sulfate (SDS) was ordered from Sigma (Saint Louis, Missouri, USA); hydroxymethylaminomethane (Tris) was obtained from Shanghai Dingguo Biotech Development Co. (Shanghai, China). [source, 2016]
Using α-NA with Physostigmine as substrate, this mixture was shaken for 10 s in the multiplate reader at 30 °C. [source, 2016]
Numerous studies investigated the preventive effects of Galantamine [8], Physostigmine [9], Naloxone [10], Dexamethasone [11], and piracetam [12] on ECT-associated memory deficit. [source, 2015]
There also is some information about the use of Physostigmine, thyroid hormone, and Naloxone, indicating that they can reduce the psychological effects of ECT, but their effects are not well studied and identified yet. [source, 2015]
Our findings are consistent with previous studies in rodents that have demonstrated that basal forebrain-derived acetylcholine is important for tasks involving cues and cue detection including feature binding (Parikh et al., 2007; Botly and De Rosa, 2009), as well as a report that enhancement of cholinergic neuromodulation using Physostigmine, an acetylcholine esterase inhibitor, increases the selectivity of neural responses during visual working memory tasks in humans (Furey et al., 2000). [source, 2015]
Examples of non-selective nAChR PAMs include Physostigmine and galantha-mine and selective α4β2 nAChR PAMs include dFBr (desformylflustrabromine), NS9283 (3-[3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl]benzonitrile, and CMPI (3-(2-chlorophenyl)-5-(5-methyl-1-(piperidin-4-yl)-1H-pyrrazol-4-yl)isoxazole; Figure 2). [source, 2015]
Galanthamine and Physostigmine are used clinically as acetylcholinesterase inhibitors. [source, 2015]