Latest research on Pregabalin

Pregabalin is an anticonvulsant drug used for neuropathic pain, as an adjunct therapy for partial seizures, and in generalized anxiety disorder. It was designed as a more potent successor to gabapentin. Pregabalin is marketed by Pfizer under the trade name Lyrica. It is considered to have a dependence liability if misused, and is classified as a Schedule V drug in the U.S. [Wikipedia]

Latest findings

His medications included Duloxetine, Quetiapine, Pregabalin, and methadone 20 mg in the morning and 15 mg in the evening for pain relief. [source, 2015]
Pregabalin is a medicine that relieves pain. [source, 2016]
Clinical studies suggested that administration of Pregabalin is effective against diabetic peripheral neuropathy. [source, 2016]
The incidence of these adverse effects increases with larger Pregabalin doses [8, 10]. [source, 2016]
Therefore, a combination of Pregabalin and radon treatment has beneficial effects to reduce the adverse effects of Pregabalin and the lung cancer risk caused by radon inhalation. [source, 2016]
The purpose of this study was to compare the mitigating effects on CCI of radon inhalation and Pregabalin administration and to examine the combination effects of radon and Pregabalin on CCI-induced neuropathic pain. [source, 2016]
We assayed the behavioural response to evaluate the pain and the following biochemical parameters to assess the effects of radon and Pregabalin treatment: SOD activity, catalase activity, total Glutathione content (t-GSH), and lipid peroxide level in paw. [source, 2016]
The behavioral response of mice to mechanical stimuli was assessed using the von Frey test [12]. von Frey tests were conducted once a day before (2 or 3 days) and after (2 or 3 days) CCI surgery and at 30, 60, 90, and 120 min after Pregabalin administration, 24-hour radon inhalation, or a combination of radon inhalation and Pregabalin administration. [source, 2016]
In the group treated with radon and Pregabalin, mice were administered Pregabalin immediately after radon inhalation. [source, 2016]
Pregabalin (1, 3, or 10 mg/kg body weight; Sigma-Aldrich Japan Co. LLC. [source, 2016]