Latest research on Pregabalin

Pregabalin is an anticonvulsant drug used for neuropathic pain, as an adjunct therapy for partial seizures, and in generalized anxiety disorder. It was designed as a more potent successor to gabapentin. Pregabalin is marketed by Pfizer under the trade name Lyrica. It is considered to have a dependence liability if misused, and is classified as a Schedule V drug in the U.S. [Wikipedia]

Pregabalin indications

Clinical studies suggested that administration of Pregabalin is effective against diabetic peripheral neuropathy. [source, 2016]
The incidence of these adverse effects increases with larger Pregabalin doses [8, 10]. [source, 2016]
Therefore, a combination of Pregabalin and radon treatment has beneficial effects to reduce the adverse effects of Pregabalin and the lung cancer risk caused by radon inhalation. [source, 2016]
The purpose of this study was to compare the mitigating effects on CCI of radon inhalation and Pregabalin administration and to examine the combination effects of radon and Pregabalin on CCI-induced neuropathic pain. [source, 2016]
We assayed the behavioural response to evaluate the pain and the following biochemical parameters to assess the effects of radon and Pregabalin treatment: SOD activity, catalase activity, total Glutathione content (t-GSH), and lipid peroxide level in paw. [source, 2016]
To examine the combination effects of radon and Pregabalin, mice were administered Pregabalin at a dose of 3 mg/kg of body weight immediately after radon inhalation. [source, 2016]
Results showed that the peak of the mitigative effects was at around one hour after Pregabalin administration. [source, 2016]
Then, we compared the mitigative effects of radon inhalation and Pregabalin administration at one hour after treatment of radon or Pregabalin because the peak of mitigative effects is at around one hour after Pregabalin administration. [source, 2016]
As a result, radon inhalation has a mitigating effect against mechanical allodynia similar to the effects of approximately 1.4 mg/kg of body weight of Pregabalin (Figure 2(c)). [source, 2016]
To clarify the combined effects of radon and Pregabalin on neuropathic pain, von Frey tests were conducted. [source, 2016]