Latest research on Pregabalin

Pregabalin is an anticonvulsant drug used for neuropathic pain, as an adjunct therapy for partial seizures, and in generalized anxiety disorder. It was designed as a more potent successor to gabapentin. Pregabalin is marketed by Pfizer under the trade name Lyrica. It is considered to have a dependence liability if misused, and is classified as a Schedule V drug in the U.S. [Wikipedia]

Pregabalin side effects

The incidence of these adverse effects increases with larger Pregabalin doses [8, 10]. [source, 2016]
Therefore, a combination of Pregabalin and radon treatment has beneficial effects to reduce the adverse effects of Pregabalin and the lung cancer risk caused by radon inhalation. [source, 2016]
Then, we compared the mitigative effects of radon inhalation and Pregabalin administration at one hour after treatment of radon or Pregabalin because the peak of mitigative effects is at around one hour after Pregabalin administration. [source, 2016]
Although no significant changes were observed in the activities of SOD and catalase, Pregabalin administration increased t-GSH content in paw. [source, 2016]
The lipid peroxide level in the paw of mice, which were administrated Pregabalin at a dose of 10 mg/kg of body weight, significantly decreased (Figure 3). [source, 2016]
The 50% paw withdrawal threshold of mice treated with Pregabalin (60 min) or radon and Pregabalin (30 min, 60 min) was significantly increased. [source, 2016]
Therefore, this combined effect is probably an additive effect because of the mitigating effect of radon similar to the effects of approximately 1.4 mg/kg of body weight of Pregabalin. [source, 2016]
The t-GSH contents of mice treated with Pregabalin, radon, or radon and Pregabalin following CCI surgery were significantly increased compared with that of CCI surgery received mice (Figure 5). [source, 2016]
Interestingly, antioxidant associated substances of mice treated with a combination of radon and Pregabalin were increased. [source, 2016]
Although the t-GSH of mice treated with Pregabalin increased, the activities of SOD and catalase did not increase. [source, 2016]