Latest research on Eprex

Human erythropoietin (recombinant), produced by CHO cells.

Eprex interactions

Commercial lots of Erythropoietin (Procrit) IFNβ-1a (Avonex), and heparin were used. [source, 2015]
Following concerns for transmission of Creutzfeldt-Jacob disease, human serum albumin was removed from Eprex and replaced by polysorbate 80 and Glycine [3]. [source, 2015]
In a retrospective review of 47 patients with erythropoietin-induced PRCA, all patients developed this entity after receiving Epoetin alfa (Eprex, Ortho Biotech) [12]. [source, 2015]
Globuren (Epoetin alpha) users were grouped with Eprex users, while Nespo users were grouped with Aranesp users, as these products were co-marketed. [source, 2015]
ESA users switched more frequently to Eprex (29.4 % of total switchers), which is the reference product of Epoetin alpha. [source, 2015]
The relatively high alert is possibly explained by the case of Eprex (Epoetin alfa), of note not a biosimilar, but an originator compound that had undergone changes in its production process that then led to the development of autoantibodies and pure red blood cell aplasia in some patients.57 [source, 2015]
Colony-forming cell (CFC) assays used M3234 supplemented with rat SCF (100 ng/ml); mouse IL-3 (0.01 ng/ml) and Eprex (10 U/ml) (FDCPmix); and M3434 or M3234 supplemented with mouse SCF (100 ng/ml), mouse IL-3, IL-11, GM-CSF, and Tpo (10 ng/ml), and Eprex (10 U/ml). [source, 2015]
She also received Procrit for anemia and her hypertension and diabetes mellitus type II were controlled with Lasix, Lisinopril, Hydrochlorothiazide, and Metformin. [source, 2014]
Human fetal liver erythroblasts obtained from Novogenix Laboratories, LLC., were resuspended in IMDM medium (GIBCO) supplemented with 20% FBS and 2mM L-Glutamine (Invitrogen) and treated 15 hours with 10U/mL of erythropoietin (Epogen, Amgen). [source, 2014]
Cells were pre-treated for 2 hours with two different Stat5 inhibitors: 10 μM Pimozide (Sigma) or 200 μM N′-((4-Oxo-4H-chromen-3-yl)methylene)nicotinohydrazide (Calbiochem) and incubated overnight (15h) with 10 U/mL of human recombinant erythropoietin (Epogen, Amgen). [source, 2014]