Latest research on Propranolol

A widely used non-cardioselective beta-adrenergic antagonist. Propranolol is used in the treatment or prevention of many disorders including acute myocardial infarction, arrhythmias, angina pectoris, hypertension, hypertensive emergencies, hyperthyroidism, migraine, pheochromocytoma, menopause, and anxiety. [PubChem]

Latest findings

To investigate if β-adrenergic signalling is required for the effects of stress on intratumoural LVD, we treated mice with Propranolol, a non-selective β-adrenoceptor antagonist (beta-blocker; BB) that is used clinically for the treatment of hypertension. [source, 2016]
Treatment with Propranolol during MDA-MB-231 tumour development blocked chronic stress from increasing tumour LYVE-1+ LVD and reduced metastasis to lymph nodes, suggesting that reduced LVD had functional effects on tumour cell dissemination (Fig. 3a and Supplementary Table 1). [source, 2016]
For BB studies, mice received Propranolol (Sigma; 5 mg kg−1 day−1) by mini-osmotic pump (Alzet, model 1004). [source, 2016]
The secondary objectives of the trial were to compare the effectiveness and adverse effects of two antihypertensive drugs bendrofluzide and Propranolol. [source, 2016]
Previous researches have shown that Propranolol has no beneficial effects on elastic fiber fragmentation or aortic wall structure, whereas losartan-treated mice show definite improvement in both parameters. [source, 2016]
In dynamic experiments, cells were stimulated with UK14,304 (10μM), Yohimbine (60μM), Bradykinin (1μM), LPA (1μM), Carbachol (100μM), Atropine (10μM), Isoproterenol (10μM), Propranolol (10μM), S1P (500nM), 20μM or 100μM Norepinephrine or 30μM adenosine at the indicated time points. [source, 2016]
Several other CADs exerted collapse of the DMS, including Imipramine, verapamil, Propranolol, bupavaciane (Table S3). [source, 2016]
Interestingly, LTP or LTD elicited with electrical stimulation, and which lasts for over 24 h, is not altered by Propranolol, a β-AR antagonist (Hagena and Manahan-Vaughan 2012). [source, 2016]
What is interesting here is that β-AR antagonism with Propranolol did not block the potentiation, but it did suppress the effect seen by glutamate activation (Harley et al. 1989). [source, 2016]
Propranolol, an antagonist of β2 receptor, reversed this effect. [source, 2016]