Latest research on Prostaglandin e1

Alprostadil is produced endogenously and causes vasodilation by means of a direct effect on vascular and ductus arteriosus (DA) smooth muscle, preventing or reversing the functional closure of the DA that occurs shortly after birth. This results in increased pulmonary or systemic blood flow in infants. In infants, it is used for palliative, not definitive, therapy to temporarily maintain the patency of the ductus arteriosus until corrective or palliative surgery can be performed in neonates who have congenital heart defects and who depend upon the patent ductus for survival. In adults, it is used for the treatment of erectile dysfunction due to neurogenic, vasculogenic, psychogenic, or mixed etiology.

Latest findings

When first-line pharmaceuticals such as phosphodiesterase type 5 (PDE5) inhibitors fail, intracavernous injection (ICI), vacuum devices or intraurethral Alprostadil are options considered. [source, 2016]
Patients not responding to oral therapy may be offered ICIs, and prostaglandin E1 (Alprostadil) is the most common drug; different formulations include Bimix (papaverine and Phentolamine) and Trimix (Alprostadil, papaverine and Phentolamine). [source, 2016]
Primary tubular epithelial cells were isolated from the kidneys and were maintained in DMEM/F12 containing 10% fetal calf serum, 1% penicillin–streptomycin, 125 ng ml−1 Prostaglandin e1 (Calbiochem, Germany), 25 ng ml−1 EGF, 1.8 μg ml−1 L-Thyroxine, 3.38 ng ml−1 Hydrocortisone and 2.5 mg ml−1 of insulin–transferrin—sodium selenite supplement (all from Sigma Aldrich, Germany unless mentioned). [source, 2016]
Another report is about Tangshenqing (TSQ) combined with Alprostadil in the treatment of DN patients [129]. [source, 2016]
After administration of intravenous heparin and Prostaglandin e1, the pulmonary artery and vein were clamped, and the right pneumonectomy was completed. [source, 2016]
Misoprostol is a Prostaglandin e1 methyl ester and is used orally for the prevention or treatment of peptic ulcer. [source, 2016]
Despite intensive conservative therapy including Alprostadil, Argatroban, and sarpogrelate, lower extremity ischemia progressed. [source, 2016]
Dietary nutrients as cofactors are necessary for the formation of potent platelet anti-aggregators and vasodilators such as Prostaglandin e1 (PGE1) and PGI3, which can prevent the development of hypertension [32]. [source, 2016]
For example, Epoprostenol has some affinity for the vasoconstrictive Prostaglandin e1 (EP1), prostaglandin E3 (EP3), and thromboxane (TP) receptors, while Treprostinil can also bind the vasodilatory Prostaglandin E2 (EP2) and prostaglandin D2 (DP1) receptors. [source, 2016]
Prostaglandin E1 (PGE1), also termed Alprostadil, is an endogenous substance, which has numerous effects, including vasodilation, protection of endothelial cells, and inhibition of the activation and aggregation of neutrophils and thrombocytes (9). [source, 2015]