Latest research on Prostaglandin e1

Alprostadil is produced endogenously and causes vasodilation by means of a direct effect on vascular and ductus arteriosus (DA) smooth muscle, preventing or reversing the functional closure of the DA that occurs shortly after birth. This results in increased pulmonary or systemic blood flow in infants. In infants, it is used for palliative, not definitive, therapy to temporarily maintain the patency of the ductus arteriosus until corrective or palliative surgery can be performed in neonates who have congenital heart defects and who depend upon the patent ductus for survival. In adults, it is used for the treatment of erectile dysfunction due to neurogenic, vasculogenic, psychogenic, or mixed etiology.

Prostaglandin e1 and alcohol

We excluded patients with active chronic otitis media, acute otitis media, otitis media with effusion or dysfunction of the auditory tube, a history of previous treatments (except for systemic application of glucocorticoids or Prostaglandin e1), malignant tumours, severe liver dysfunction (aspartate aminotransferase (AST) >100 IU/L and Alanine aminotransferase (ALT) >100 IU/L), uncontrolled diabetes (haemoglobin A1C (HbA1c) >10%), pituitary or adrenal dysfunction, severe systemic illness that affected life expectancy, a history of severe drug allergy, or a history of alcohol or drug dependence within the past 1 year, and pregnant or lactating women. [source, 2010]
Prostaglandin e1 alcohol (PGE1-OH) and NS-398 were obtained from Cayman Chemical. [source, 2008]