Latest research on Prostaglandin e1

Alprostadil is produced endogenously and causes vasodilation by means of a direct effect on vascular and ductus arteriosus (DA) smooth muscle, preventing or reversing the functional closure of the DA that occurs shortly after birth. This results in increased pulmonary or systemic blood flow in infants. In infants, it is used for palliative, not definitive, therapy to temporarily maintain the patency of the ductus arteriosus until corrective or palliative surgery can be performed in neonates who have congenital heart defects and who depend upon the patent ductus for survival. In adults, it is used for the treatment of erectile dysfunction due to neurogenic, vasculogenic, psychogenic, or mixed etiology.

Prostaglandin e1 dosage

The patient used a 20 µg strength injector to deliver a dose of 20 µg of Alprostadil. [source, 2015]
Raina et al. have treated 56 men with intraurethral Alprostadil (MUSE, Vivus Inc., Mountain View, California, USA) at doses of 125 and 250 mg three times weekly for 9 months. [source, 2015]
Three cardiovascular drugs – Dopamine (DOA; minimal dose, 1 μg/kg · min), Nitroglycerine (NTG; minimal dose, 0.1 μg/kg · min), and Prostaglandin e1 (PGE1; minimal dose, 0.005 μg/kg · min) – were administered as part of our routine institutional procedure for the preservation of renal, coronary, and peripheral circulation, respectively. [source, 2014]
Various agents that have been tried for the treatment include steroids, methotrexate, Cyclosporine, radiotherapy, Prostaglandin e1, factor XIII, systemic photochemotherapy with psoralene and ultraviolet A (PUVA), high dose penicillin, d-penicillamine etc [4, 8]. [source, 2014]
Women with postpartum hemorrhage received additional doses of Oxytocin and other uterotonic agents including Methylergonovine, prostaglandin F2 alpha, and Prostaglandin e1, per the obstetrician's discretion. [source, 2014]
She had recurrent severe acute pulmonary edema and hypoxemic respiratory failure despite high dose inhaled Alprostadil (160 mcg/hr), 100% FiO2, and PEEP of 10 cm H2O. [source, 2014]
All but two of these patients additionally received antiplatelet therapy by intravenous Prostaglandin e1 at doses of 2.5 to 5 ng/kg/min. [source, 2014]
Additionally, group III was treated intravenously with a PGE1 vasodilator at a dosage of 10 μg/kg (Prostavasin, Schwarz Pharma, Italy). [source, 2014]
In addition to supportive care measures, a number of therapeutic strategies have attempted to improve outcome including N-acetylcysteine,24,31,32 high-dose Methylprednisolone,16,33 recombinant human tissue plasminogen activator alone34,35 and in combination with heparin,9,36,37 antithrombin III,23,38 and Prostaglandin e1 in combination with heparin39 and thrombomodulin,40 although the data for their use is limited. [source, 2014]
However, the intraperitoneal injection of a high dose of Prostaglandin e1 for radiation-induced healing-impaired skin injury may have side-effects [5]. [source, 2014]