Latest research on Prostaglandin e1

Alprostadil is produced endogenously and causes vasodilation by means of a direct effect on vascular and ductus arteriosus (DA) smooth muscle, preventing or reversing the functional closure of the DA that occurs shortly after birth. This results in increased pulmonary or systemic blood flow in infants. In infants, it is used for palliative, not definitive, therapy to temporarily maintain the patency of the ductus arteriosus until corrective or palliative surgery can be performed in neonates who have congenital heart defects and who depend upon the patent ductus for survival. In adults, it is used for the treatment of erectile dysfunction due to neurogenic, vasculogenic, psychogenic, or mixed etiology.

Prostaglandin e1 interactions

Patients not responding to oral therapy may be offered ICIs, and prostaglandin E1 (Alprostadil) is the most common drug; different formulations include Bimix (papaverine and Phentolamine) and Trimix (Alprostadil, papaverine and Phentolamine). [source, 2016]
Primary tubular epithelial cells were isolated from the kidneys and were maintained in DMEM/F12 containing 10% fetal calf serum, 1% penicillin–streptomycin, 125 ng ml−1 Prostaglandin e1 (Calbiochem, Germany), 25 ng ml−1 EGF, 1.8 μg ml−1 L-Thyroxine, 3.38 ng ml−1 Hydrocortisone and 2.5 mg ml−1 of insulin–transferrin—sodium selenite supplement (all from Sigma Aldrich, Germany unless mentioned). [source, 2016]
Despite intensive conservative therapy including Alprostadil, Argatroban, and sarpogrelate, lower extremity ischemia progressed. [source, 2016]
Misoprostol is a Prostaglandin e1 methyl ester and is used orally for the prevention or treatment of peptic ulcer. [source, 2016]
For example, Epoprostenol has some affinity for the vasoconstrictive Prostaglandin e1 (EP1), prostaglandin E3 (EP3), and thromboxane (TP) receptors, while Treprostinil can also bind the vasodilatory Prostaglandin E2 (EP2) and prostaglandin D2 (DP1) receptors. [source, 2016]
Systolic blood pressure was adjusted to 75–90 mmHg during surgery using intravenous REMIFENTANIL, Alprostadil, nicardipine, and/or calcium, and/or by controlling the infusion volume. [source, 2015]
Other injectable erectogenic preparations such as Tri-Mix [7] and Alprostadil combined with Lidocaine [20] may cause less pain than Alprostadil alone and therefore may be more efficient. [source, 2015]
Insulin’s action on platelets is to sensitize platelets to the inhibitory effects of Prostacyclin and Nitric oxide on aggregation and to diminish the proaggregatory properties of agonists such as Prostaglandin e1, and E2. [source, 2015]
A second method to improve access to PAC and the level of care is the use of the Prostaglandin e1 analogue Misoprostol for medical abortions [12, 15]. [source, 2015]
For treatment of Raynaud's phenomenon the vasodilator Prostaglandin I2 analogue iloprost [6] and the prostaglandin E1 analogue Alprostadil are widely used [7]. [source, 2015]