Latest research on Prostaglandin e1

Alprostadil is produced endogenously and causes vasodilation by means of a direct effect on vascular and ductus arteriosus (DA) smooth muscle, preventing or reversing the functional closure of the DA that occurs shortly after birth. This results in increased pulmonary or systemic blood flow in infants. In infants, it is used for palliative, not definitive, therapy to temporarily maintain the patency of the ductus arteriosus until corrective or palliative surgery can be performed in neonates who have congenital heart defects and who depend upon the patent ductus for survival. In adults, it is used for the treatment of erectile dysfunction due to neurogenic, vasculogenic, psychogenic, or mixed etiology.

Prostaglandin e1 side effects

Other injectable erectogenic preparations such as Tri-Mix [7] and Alprostadil combined with Lidocaine [20] may cause less pain than Alprostadil alone and therefore may be more efficient. [source, 2015]
Regarding the Alprostadil group a decrease of ICG enhancement with −24.7% between baseline (85 hand segments) and day 7 (64 hand segments) was verified (see Table 2 and Figure 2). [source, 2015]
All three studies demonstrated an inhibition of TNF-α production by Prostaglandin e1 (PGE1), PGE2 or PGE3, with a simultaneous increase of either IL-6 [21] or IL-10 production [37,38]. [source, 2015]
The findings reported here suggest that apremilast and A2AR activation most likely interact by either transient cAMP signals and/or by compartmentalized cAMP increases, as previously found for Prostaglandin e1 (PGE1), which triggers transient increases in the cAMP concentration near the plasma membrane, but not in total intracellular cAMP levels [44]. [source, 2015]
Although the study was partially limited by the relatively small number of patients evaluated, early administration of Alprostadil significantly increased the recovery rates of EF after surgery. [source, 2015]
Because we primarily obtained purified Liple from the E. coli expression system, which showed no biochemical activity, the difference in the immuno-reactivities of LipLMs and Liple was also determined through ELISA assays. [source, 2015]
Cautious use of Prostaglandin e1 (PGE1) is advised as it can increase pulmonary artery pressure and worsen PR and TR and worsen heart failure. [source, 2015]
Misoprostol, a Prostaglandin e1 analogue was used in obstetrics because of its uterotonic and cervical ripening effects in different studies (7, 10). [source, 2015]
The precise mechanism is still unclear; however, it may involve PGE-1, which increases the aqueous outflow, or an alternative pathway involving PGF-2 [20, 21]. [source, 2015]
In the case of increased PAP, PAP-lowering agents, including Nitroglycerine, inhaled Nitric oxide, Prostaglandin e1 or Prostaglandin I2, should be considered [4]. [source, 2014]