Latest research on Quetiapine

Quetiapine is indicated for the treatment of schizophrenia as well as for the treatment of acute manic episodes associated with bipolar I disorder. The antipsychotic effect of quetiapine is thought by some to be mediated through antagonist activity at dopamine and serotonin receptors. Specifically the D1 and D2 dopamine, the alpha 1 adrenoreceptor and alpha 2 adrenoreceptor, and 5-HT1A and 5-HT2 serotonin receptor subtypes are antagonized. Quetiapine also has an antagonistic effect on the histamine H1 receptor.

Latest findings

Concerning medication, three patients were free of any antipsychotic medication, the others received mono- or dual therapy with atypical antipsychotic medication including Amisulpride (n = 2), Olanzapine (n = 11), Clozapine (n = 4), Quetiapine (n = 2), Ziprasidone (n = 1), Risperidone (n = 5), Aripiprazole (n = 2), Paliperidone (n = 3; cp. [source, 2016]
Seventy-five patients were taking atypical antipsychotics (Risperidone, Paliperidone, Clozapine, Aripiprazole, Ziprasidone, and/or Quetiapine) at a median Chlorpromazine equivalent dose of 349.20 (277.64) mg/day. [source, 2016]
Although genetic and lifestyle factors may also account for abnormal glucose homeostasis and frank diabetes with antipsychotic treatment, it is likely that the low prevalence of diabetes mellitus in this study is due to the underutilization of antipsychotics with a higher liability for diabetes mellitus such as Clozapine, Olanzapine and Quetiapine [40]. [source, 2016]
Several pharmacological therapies for insomnia have been formulated, including benzodiazepine receptor antagonists (BzRAs) (eg, benzodiazepines and nonbenzodiazepine sedative-hypnotics, such as Zolpidem, Zaleplon, and Eszopiclone), Melatonin, Melatonin-receptor agonists, and various antidepressant medications including Quetiapine, Amitriptyline, Mirtazapine, and Trazodone. [source, 2016]
Data on individual AP drugs are more controversial, with individual phenothiazines and butyrophenones (e.g., Haloperidol) carrying a higher risk as compared with some individual second-generation AP drugs, such as Quetiapine and Olanzapine, which may have a moderate risk, or Aripiprazole, possibly showing a lower potential to cause QTc prolongation [3;4]. [source, 2016]
In addition, we tested whether use of Haloperidol, Risperidone, Olanzapine, Clozapine, Quetiapine, Paliperidone or Aripiprazole was associated with QTc interval. [source, 2016]
In terms of drug treatments, use of Haloperidol, Clozapine, Quetiapine and Aripiprazole was more frequent in patients treated with AP polypharmacy (Table 1). [source, 2016]
The most frequently prescribed antidepressants and atypical antipsychotics were Escitalopram and Quetiapine, respectively. [source, 2016]
A study that examined the effect of antipsychotics on DNA methylation found that Clozapine and Quetiapine reduced the DNA methylation, but there are no similar effects of Haloperidol and Risperidone on DNA methylation status [54]. [source, 2016]
Of the patients under antidepressant drug therapy, 27 (24.3%) were using Venlafaxine, under antipsychotic drug therapy, 49 (44.4%) were using Quetiapine. [source, 2016]