Latest research on Quetiapine

Quetiapine is indicated for the treatment of schizophrenia as well as for the treatment of acute manic episodes associated with bipolar I disorder. The antipsychotic effect of quetiapine is thought by some to be mediated through antagonist activity at dopamine and serotonin receptors. Specifically the D1 and D2 dopamine, the alpha 1 adrenoreceptor and alpha 2 adrenoreceptor, and 5-HT1A and 5-HT2 serotonin receptor subtypes are antagonized. Quetiapine also has an antagonistic effect on the histamine H1 receptor.

Quetiapine and alcohol

Quetiapine has been used, with varying degrees of success, to aid in treating withdrawal symptoms from abused substances (ie, alcohol, Cocaine, benzodiazepines, opioids) and increasing abstinence. [source, 2015]
Quetiapine has been used to treat insomnia in patients in early recovery from alcohol dependence but with inconsistent results.22,23 [source, 2015]
The main acute adverse effect of Quetiapine is somnolence, and prescription labels warn to avoid using with alcohol. [source, 2015]
Across these studies, use of Quetiapine in conjunction with alcohol was often reported. [source, 2015]
Alcohol plays a role in about one-third of the MUA and suicide attempt visits involving Quetiapine in combination but is infrequently observed in adverse events (7%). [source, 2015]
Majority of endotracheal intubations (ETIs) that occur on patients are related with medical emergencies, including; Head and brain injuries, cervical and spinal cord injuries, chronic obstructive pulmonary disease (COPD), croup, airway obstructions, asthma, massive hemoptysis, myxedema coma, malignant interventions (thyroid carcinoma), pediatric emergencies, congenital diaphragmatic hernia in newborns, pediatric tumors, exposure to chemicals, drugs, over dosage and poisoning, [neurotoxins, Ziprasidone, Phenol, dettol, pine oil, isopropyl alcohol, domestos, Quetiapine, organophosphates (OP), Phenytoin, Topiramate, ketamine], and other conditions which necessitate intubation, either prehospital or in hospital emergency. [source, 2015]
Clinical studies suggest that some atypical antipsychotics, such as Clozapine, Olanzapine, and Quetiapine, may reduce alcohol craving and consumption, especially among patients with comorbid psychopathology. [source, 2015]
Similar benefits of Quetiapine in reducing alcohol use and craving were also reported in posttraumatic stress disorder. [source, 2015]
In a recent open-label study, Quetiapine decreased alcohol consumption, craving for alcohol, and psychiatric symptoms intensity while maintaining a good level of tolerance. [source, 2015]
These protective effects may explain the clinical observations that Quetiapine reduced psychiatric symptoms intensity and maintained a good level of tolerability in chronic alcoholism with comorbid psychopathology.8,48,49 [source, 2015]