Latest research on Quetiapine

Quetiapine is indicated for the treatment of schizophrenia as well as for the treatment of acute manic episodes associated with bipolar I disorder. The antipsychotic effect of quetiapine is thought by some to be mediated through antagonist activity at dopamine and serotonin receptors. Specifically the D1 and D2 dopamine, the alpha 1 adrenoreceptor and alpha 2 adrenoreceptor, and 5-HT1A and 5-HT2 serotonin receptor subtypes are antagonized. Quetiapine also has an antagonistic effect on the histamine H1 receptor.

Quetiapine side effects

Data on individual AP drugs are more controversial, with individual phenothiazines and butyrophenones (e.g., Haloperidol) carrying a higher risk as compared with some individual second-generation AP drugs, such as Quetiapine and Olanzapine, which may have a moderate risk, or Aripiprazole, possibly showing a lower potential to cause QTc prolongation [3;4]. [source, 2016]
Based on findings in the present meta-analysis, Quetiapine may have an effective role in the treatment of such patients because of its better Sleep promoting quality compared to SSRIs. [source, 2016]
The relative low acceptability and tolerability of higher dose Quetiapine may be caused by its adverse events. [source, 2016]
Although low dose Quetiapine appears to be effective and tolerable in the treatment of GAD patients, use of this active agent in clinical practice should be cautiously carried out because of adverse events. [source, 2016]
Quetiapine labeling carries the same warning as antidepressants for possible increased risk of suicidal thoughts and actions. [source, 2015]
The leading cause of Quetiapine visits for each year was MUA. [source, 2015]
The number of visits for MUA of Quetiapine from 2005 to 2011 increased 67% from 19,195 to 32,024, but the difference did not reach statistical significance (P = 0.06); visits for suicide attempts increased significantly by 90%, from 8,645 visits to 16,413, and adverse reactions increased significantly by 146%, from 7,741 visits to 19,060. [source, 2015]
Studies in Australia have suggested that the increased availability of Quetiapine as a result of prescribing trends is responsible for heightened ambulance rescues in metropolitan Melbourne from 2001 to 2010.37 Although this provides strong support for increasing levels of adverse reactions, the relationship between prescribing levels and ED visits involving MUA and suicides is likely more complex. [source, 2015]
The fact we did not observe Cocaine as a major co-occurring drug in ED visits may be because Cocaine and Quetiapine taken together do not produce desirable effects or the combination is less likely to result in an acute medical emergency. [source, 2015]
However, the rate of Haloperidol prescription decreased from 19.1% in 2005 to 1.9% in 2010 (Fisher’s exact test; p=0.006), and the rate of Quetiapine prescription increased from 6.2% in 2005 to 27.4% in 2010 (χ2= 31.434; p<0.001). [source, 2015]