Latest research on Remicade

Tumor necrosis factor (TNF-alpha) binding antibody (chimeric IgG1). It is composed of human constant and murine variable regions. Infliximab is produced by a recombinant cell line cultured by continuous perfusion

Remicade indications

Previously we have demonstrated the effects of a tumor necrosis factor-alpha (TNF-α) inhibitor infliximab's (Remicade, Merck&Co, Whitehouse Station, NJ, USA) effects on different experimental models of neuronal injury24,31,32). [source, 2015]
Introduction: Remicade (INN-infliximab, IFX) has proven to be effective in inducing and maintaining remission of Crohn’s disease and ulcerative colitis. [source, 2015]
Infliximab (Remicade) is a chimeric monoclonal antibody (mAb) that recognizes and binds TNFα, neutralizing its biological effects [7]. [source, 2015]
Remsima was authorized in 2013 by the European Medicines Agency (EMA) for the same indications as the reference product Remicade [30]. [source, 2015]
Remsima was the first biosimilar antibody to meet the stringent EMA criteria for extrapolation of indications [31]. [source, 2015]
The results indicate that Remicade might be cost-effective in some patient groups, but appears unlikely to be cost-effective in others. [source, 2015]
Furthermore, even in cases where Remicade is cost-effective, any savings made are insufficient to offset the additional drug-acquisition and administration costs [45, 46] (see Appendix A for a nonsystematic literature review on the cost-effectiveness of Remicade). [source, 2015]
The present budget impact analysis was designed to estimate the budget impact of the introduction of Remsima across the six licensed indications in these five European countries. [source, 2015]
The number of patients currently treated with Remicade was found to have a considerable, but less important, directly correlating effect on the projected savings. [source, 2015]
In addition, TNF inhibitors, including Enbrel, Remicade, Humira, have been accepted as the most effective anti-inflammatory therapeutics and the most successful biotech drugs5152. [source, 2014]