Latest research on Remicade

Tumor necrosis factor (TNF-alpha) binding antibody (chimeric IgG1). It is composed of human constant and murine variable regions. Infliximab is produced by a recombinant cell line cultured by continuous perfusion

Remicade interactions

100 mg of Infliximab powder (Remicade) were dissolved in 1mL of sterilized distilled water, 24 mL of BSS were added and 4 mg/ mL of Eye Drops were produced. [source, 2015]
Biologic disease-modifying antirheumatic drugs (bDMARDs), also known as biologics, cover TNF inhibitors (TNFi) (adalimumab (ADA) (Humira, AbbVie Ltd.), certolizumab pegol (CER) (Cimzia, UCB Pharma SA), etanercept (ETN) (Enbrel, Pfizer Ltd.), golimumab (GOL) (Simponi, Janssen Biologics B.V), infliximab (IFX) (Remicade, Janssen Biologics B.V.)) and agents based on other mechanisms of action (abatacept (ABT) (Orencia, Bristol-Myers Squibb Pharma EEIG), anakinra (ANA) (Kineret, Biovitrum AB), rituximab (RTX) (MabThera, Roche Registration Ltd) and tocilizumab (TOC) (RoActemra, Roche Registration Ltd. [source, 2015]
The annual sales of the top-selling antibody drugs, such as Humira, Remicade, Avastin, Rituxan and Herceptin, are over or close to $ 10 billion now while many potential blockbusters are being investigated in clinical trials [1, 2]. [source, 2015]
Five top-selling therapeutic antibodies which are also popular biosimilar candidates for many biotech companies, namely Herceptin (trastuzumab), Avastin (bevacizumab), Remicade (infliximab), Rituxan (rituximab) and Humira (adalimumab), were used as model molecules in this study. [source, 2015]
The optimized signal peptides for Herceptin, Avastin, Remicade, Rituxan and Humira were identified. [source, 2015]
The variable regions and the constant regions of the HC and LC of Herceptin, Avastin, Remicade, Rituxan and Humira were generated based on publicly available information. [source, 2015]
Interestingly, the HC signal peptide 7 (H7) resulted in significantly increased secretion for Avastin, Remicade, Rituxan and Humira. [source, 2015]
The results shown in Fig. 2 confirmed that the best signal peptide combination for the production of Herceptin, Avastin, Remicade, Rituxan and Humira are H5/L1, H7/L1, H7/L2, H7/L2 and H7/L1 respectively. [source, 2015]
Results shown in Fig. 2 also suggest that under these experimental conditions with our optimized signal peptides, Herceptin is produced most efficiently in CHO cells, followed by Rituxan, Avastin, Humira, and lastly Remicade. [source, 2015]
For some antibodies (Herceptin, Avastin and Humira), the antibody productivity was higher when L1 LC was utilized, whereas for others (Rituxan and Remicade) L2 LC resulted in higher productivity of the antibody, suggesting that the LC signal peptide also affects the overall productivity of the antibody. [source, 2015]