Latest research on Risperidone

Risperidone, a benzisoxazole derivative, is an atypical antipsychotic drug with high affinity for 5-hydrotryptamine (5-HT) and dopamine D2 receptors. It is used primarily in the management of schizophrenia, inappropriate behavior in severe dementia and manic episodes associated with bipolar I disorder. Risperidone is effective for treating the positive and negative symptoms of schizophrenia owing to its affinity for its “loose” binding affinity for dopamine D2 receptors and additional 5-HT antagonism compared to first generation antipsychotics, which are strong, non-specific dopamine D2 receptor antagonists.

Latest findings

In the present study, we have used PCP and Amphetamine in the paired click paradigm in conscious rats i) to model disturbances in the AEP waveform components observed in schizophrenia and ii) to evaluate the degree to which the mGluR2 agonist LY404039 [48] and the PDE10 inhibitor PQ-10 [51] could improve PCP and Amphetamine-induced auditory processing deficits as was observed with atypical antipsychotics Risperidone and Olanzapine, respectively. [source, 2016]
The test drugs were Risperidone (0.64 mg/kg), Olanzapine (2.5 mg/kg), LY403939 (10 mg/kg) and PQ-10 (3 mg/kg). [source, 2016]
The doses of Risperidone and Olanzapine were selected based on Dopamine D2 receptor occupancy and their potency to attenuate the challenge-induced hyperlocomotor behaviour. [source, 2016]
Subsequently, it was determined to what extent the atypical antipsychotics Risperidone (0.64 mg/kg) and Olanzapine (2.5 mg/kg) would normalize PCP and amphetamine-induced aberrant AEP waveform components and EEG oscillations, respectively. [source, 2016]
All drugs were synthesized at Janssen Research and Development laboratories and were prepared and administered as follow: Risperidone and Olanzapine (H2O + 2H2T + NaCl, subcutaneous), PCP and Amphetamine (H2O + NaCl, subcutaneous). [source, 2016]
In accordance with this model, the present work demonstrated that both atypical antipsychotics Risperidone and Olanzapine increased peak amplitudes to S1 stimuli and attenuated Amphetamine and PCP-induced altaerations in AEP peak amplitudes, respectively. [source, 2016]
In line with these observations, pretreatment with the atypical antipsychotics Risperidone and Olanzapine consistently reduced PCP and amphetamine-induced transient pathological enhanced higher gamma and alpha frequency oscillations. [source, 2016]
Atypical antipsychotics, such as Risperidone, are the second-generation antipsychotic drugs which are efficient to reduce both positive and negative symptoms, without important prejudice of physiological effects of Dopamine via nigro-striatal. [source, 2016]
Lai et al. [11] have shown, using pragmatic outcome measures, that the effectiveness of sulpiride was better than Haloperidol and Risperidone. [source, 2016]
In an earlier study [16], we used the spectrofluorimetric binding analysis [17] to explore the interaction of Risperidone with albumins. [source, 2016]