Latest research on Ritonavir

An HIV protease inhibitor that works by interfering with the reproductive cycle of HIV. [PubChem]

Latest findings

In fact, co-administration with a strong CYP3A inhibitor such as Cobicistat (COBI) or Ritonavir (RTV) has resulted in maintenance of high systemic exposure and prolonged elimination half-life. [source, 2016]
Furthermore, Ethanol exposure significantly decreased the IC50 values of Amprenavir, Darunavir, and nelfinavir but robustly elevated the IC50 of Indinavir and Ritonavir [12, 13], suggesting a differential impact of Ethanol on the binding and bio-transformation of protease inhibitors. [source, 2016]
Most notably, it has been suggested that Ritonavir (usually co-administred with lopinavir as Lopimune or Kaletra) may have anti-invasive and anti-proliferative activity against cells derived from pre-invasive CINs but little activity against cells derived from more advanced ICC [20]. [source, 2016]
Elvitegravir, Ritonavir, and cobicistat were purchased from Toronto Research Chemicals Inc. (Ontario, Canada). [source, 2016]
Each patient was then issued with a supply of Lopimune soft gel capsules (133 mg lopinavir/33 mg Ritonavir, CIPLA, India) for vaginal insertion of one capsule once or twice daily for a maximum of 2 weeks with the intention of block radomising the dose. [source, 2016]
When used for oral HIV therapy, Lopinavir is normally co-adminstered in a 4:1 ratio with Ritonavir (Lopimune- CIPLA; Kaletra- AbbVie). [source, 2016]
For example, Ritonavir, Indinavir, and saquinavir inhibit CYP3A4 at the IC50 values of 0.034, 0.43, and 2.14 μM [36]. [source, 2016]
Similar to these findings we have previously reported that Ethanol significantly alters the IC50 for the protease inhibitors Indinavir and Ritonavir by perhaps facilitating the CYP3A4 and protease inhibitors interaction through hydrogen bonding and hydrophobic interactions [39]. [source, 2016]
TAF is a prodrug of Tenofovir, which is boosted significantly by either Ritonavir or cobicistat. [source, 2016]
The dose of TAF is 10 mg once daily when co-administered with Ritonavir or cobicistat (to adjust for their boosting effects from the inhibition of p-glycoprotein) or 25 mg once daily when given without these booster drugs. [source, 2016]