Latest research on Salbutamol

Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Salbutamol is formulated as a racemic mixture of the R- and S-isomers. The R-isomer has 150 times greater affinity for the beta2-receptor than the S-isomer and the S-isomer has been associated with toxicity. This lead to the development of levalbuterol, the single R-isomer of salbutamol. However, the high cost of levalbuterol compared to salbutamol has deterred wide-spread use of this enantiomerically pure version of the drug. Salbutamol is generally used for acute episodes of bronchospasm caused by bronchial asthma, chronic bronchitis and other chronic bronchopulmonary disorders such as chronic obstructive pulmonary disorder (COPD). It is also used prophylactically for exercise-induced asthma.

Latest findings

Continuous or repetitive nebulisation of Salbutamol should be preferred because duration of activity and effectiveness of β2-agonists are inversely related to the severity of airways obstruction [13]. [source, 2002]
The usual dose is 2.5 mg of Salbutamol (0.5 ml) in 2.5 ml normal saline for each nebulisation (Table 3) [34]. [source, 2002]
Subcutaneous administration of Epinephrine or terbutaline should be considered, in patients not responding adequately to continuous nebulised Salbutamol, and in those patients unable to cooperate (depression of mental status, apnea, coma) [52] It should also be attempted in intubated patients not responding to inhaled therapy. [source, 2002]
Spirometry was obtained before and 10 minutes after inhalation of 200 μg inhaled Salbutamol. [source, 2002]
Intravenous administration of β-agonists (Epinephrine, Salbutamol) is also an option in extreme situations and should be considered in the treatment of patients who have not responded to inhaled or subcutaneous treatment, and in whom respiratory arrest is imminent, or in patients not adequately ventilated and severely hyperinflated, despite optimal setting of the ventilator. [source, 2002]
Two hours later, she inhaled 5 consecutive puffs of Salbutamol, a short acting β2-agonist, regarding the palpitation as one of asthma symptoms and the palpitation continued for 3 hr before presentation. [source, 2002]
He was treated with intravenous penicillin, hydration, and aerosolized Salbutamol. [source, 2002]
All patients required continuous low-flow oxygen therapy and were being treated with inhaled beta2-adrenergic drugs (Albuterol 600–1200 μg/day), Prednisone (5–10 mg/day), and methylxanthines (Theophylline 450–900 mg/day). [source, 2001]
Current research in asthma pharmacogenetics has highlighted associations between SNPs in the genes of β-adrenergic receptors and modified response to regular inhaled β-agonist treatments (such as Albuterol) [93,140,143, 144]. [source, 2001]
No change was observed after the inhalation of Salbutamol 200 mcg. [source, 2001]