Latest research on Salbutamol

Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Salbutamol is formulated as a racemic mixture of the R- and S-isomers. The R-isomer has 150 times greater affinity for the beta2-receptor than the S-isomer and the S-isomer has been associated with toxicity. This lead to the development of levalbuterol, the single R-isomer of salbutamol. However, the high cost of levalbuterol compared to salbutamol has deterred wide-spread use of this enantiomerically pure version of the drug. Salbutamol is generally used for acute episodes of bronchospasm caused by bronchial asthma, chronic bronchitis and other chronic bronchopulmonary disorders such as chronic obstructive pulmonary disorder (COPD). It is also used prophylactically for exercise-induced asthma.

Salbutamol and alcohol

Patients were also excluded if they: had been hospitalized for COPD/pneumonia within 12 weeks prior to Visit 1 or had undergone lung resection in the 12 months prior to screening; were hypersensitive to any anticholinergic drug or β2-agonist; were unable to withhold Salbutamol and/or Ipratropium Bromide use for the 4-hour period prior to spirometry; had a known or suspected history of alcohol or drug abuse; were participating in the acute phase of a pulmonary rehabilitation program; or had abnormal and significant findings from electrocardiogram (ECG) monitoring, 24-hour Holter monitoring, chest X-rays, clinical chemistry, or hematology tests. [source, 2014]
Since Salbutamol has poor solubility in propellant system, various concentrations of Ethyl Alcohol as cosolvent used in the range of 1-3 ml were used in the formulations D1 to D5 (Table 1). [source, 2011]
They differed significantly from those with GORD symptom scores < 12.5 with respect to alcohol consumption, asthma severity and use of oral Salbutamol but were comparable in age, gender, BMI and spirometry (Table 5). [source, 2010]