Latest research on Salbutamol

Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Salbutamol is formulated as a racemic mixture of the R- and S-isomers. The R-isomer has 150 times greater affinity for the beta2-receptor than the S-isomer and the S-isomer has been associated with toxicity. This lead to the development of levalbuterol, the single R-isomer of salbutamol. However, the high cost of levalbuterol compared to salbutamol has deterred wide-spread use of this enantiomerically pure version of the drug. Salbutamol is generally used for acute episodes of bronchospasm caused by bronchial asthma, chronic bronchitis and other chronic bronchopulmonary disorders such as chronic obstructive pulmonary disorder (COPD). It is also used prophylactically for exercise-induced asthma.

Salbutamol interactions

In the ED, he was given Albuterol and Atrovent with minimal improvement. [source, 2016]
Now several different types of inhaled beta-2 adrenergic agonists are available in clinical practice; short-acting beta-2 agonists (SABA) like Salbutamol, LABA like Salmeterol or formoterol, and ultra-LABA like indacaterol. [source, 2016]
Similarly, in an observational study DeBoeck and colleagues (1998) evaluated the combination of Salbutamol and Ipratropium Bromide by jet nebulizer and face mask to twenty spontaneously breathing subjects with BPD [47]. [source, 2016]
Brundage et al. demonstrated that the synergistic effect of combined Salbutamol and Ipratropium Bromide can promote a longer bronchodilator effect than each drug given independently [46]. [source, 2016]
The “Understanding Potential Long-term Impacts on Function with Tiotropium” study showed that at baseline 54% of the more than 5,000 patients with moderate-to-severe COPD had a reversibility when tested with 80 µg Ipratropium followed by 400 µg Salbutamol of ≥12% and ≥200 mL. [source, 2016]
Recently, Fogli et al. [30] demonstrated that the PPAR-γ ligand Rosiglitazone and β2-agonist Salbutamol had synergistic interactions on ASM proliferation. [source, 2016]
Salbutamol, terbutaline and rolipram were dissolved in Dimethyl sulfoxide (DMSO), and 8-Br-cAMP and LPS in phosphate buffered saline (PBS). [source, 2016]
Salbutamol also reduced carrageenan-induced paw edema in rats and that effect was attenuated when the β2-receptors were blocked by a non-selective β-receptor antagonist Propranolol [27]. [source, 2016]
He was prescribed inhaled corticosteroids (Fluticasone 125 μg twice daily) and beta-2 mimetics (Salbutamol as needed). [source, 2015]
He was treated with systemic corticosteroids (Prednisolone 40 mg twice daily for 5 days) and frequent use of beta-2 mimetics (Salbutamol). [source, 2015]