Latest research on Sevoflurane

Sevoflurane (2,2,2-trifluoro-1-[trifluoromethyl]ethyl fluoromethyl ether), also called fluoromethyl, is a sweet-smelling, non-flammable, highly fluorinated methyl isopropyl ether used for induction and maintenance of general anesthesia. Together with desflurane, it is replacing isoflurane and halothane in modern anesthesiology. [Wikipedia]

Latest findings

Tissue or blood samples were collected after cervical dislocation performed under Sevoflurane anesthesia or Carbon Dioxide asphyxiation, and all efforts were made to minimize animal suffering. [source, 2016]
Anesthesia was maintained with a volatile agent (Sevoflurane) and intermittent Fentanyl boluses. [source, 2016]
Propofol and Sevoflurane are commonly used anesthetics for sedation in general anesthesia, and their effects on POCD have raised the concerns of researchers. [source, 2016]
It was reported that, when compared to Sevoflurane, higher dosage of Propofol can further decrease cerebral blood flow (CBF),8 which has been, in combination with cerebral oxygenation saturation, used to assess POCD in patients undergoing valvular heart surgery. [source, 2016]
However, whether Propofol and Sevoflurane affect intraoperative cerebral oxygenation and further affect postoperative outcomes in nonheart surgery patients is unknown. [source, 2016]
In this study, Sevoflurane or Propofol was applied to different patients with preexisting cerebral oxygenation impairment in order to investigate the effects of Propofol and Sevoflurane on the cerebral oxygenation during general anesthesia and the postoperative cognitive outcomes. [source, 2016]
In this study, we compared the effects of Propofol and Sevoflurane on cerebral oxygenation and cognitive outcome in patients who underwent elective abdominal surgery. [source, 2016]
The results indicated that patients anesthetized with Sevoflurane showed better cerebral oxygenation than those with Propofol, and there was no significant difference in the SjvO2, incidence of POCD, and S100β protein levels between group S and group P. [source, 2016]
General Anesthetic Propofol has been reported to reduce CBF in equivalent proportion to cerebral metabolism, while Sevoflurane can reduce cerebral metabolism but not as much as Propofol. [source, 2016]
However, we did not find any significant difference between the two groups, suggesting that Propofol and Sevoflurane had similar effects on cerebral Oxygen consumption. [source, 2016]