Latest research on Sildenafil

Sildenfail is a vasoactive agent used to treat erectile dysfunction and reduce symptoms in patients with pulmonary arterial hypertension (PAH). Sildenafil elevates levels of the second messenger, cGMP, by inhibiting its breakdown via phosphodiesterase type 5 (PDE5). PDE5 is found in particularly high concentrations in the corpus cavernosum, erectile tissue of the penis. It is also found in the retina and vascular endothelium. Increased cGMP results in vasodilation which facilitates generation and maintenance of an erection. The vasodilatory effects of sildenafil also help reduce symptoms of PAH.

Latest findings

At the end of the study period 80% of the patients were willing to continue with Sildenafil therapy. [source, 2002]
Concerned because of the difference in appearance between the drug samples and the new tablets, the patient returned the new tablets to the pharmacy, where they were found to be Sildenafil citrate 25-mg tablets (Viagra; Pfizer Inc., New York, NY). [source, 2002]
The use of Sildenafil has also been reported recently.95 [source, 2002]
For Sildenafil, for instance, 85% of first time prescriptions occurred in the first 12 weeks of availability in one New England healthcare provider [7]. [source, 2002]
We did this with reference to the erectile dysfunction treatment sildenafil (Viagra), using clinical trial reports made available by Pfizer Ltd. [source, 2002]
All studies described withdrawals clearly and were performed on an intention-to-treat basis incorporating patients with unsuccessful attempts for reasons not associated with Sildenafil. [source, 2002]
More men responded positively to the global question about improved erections with Sildenafil than with placebo (Table 3, Figure 3). [source, 2002]
The weighted mean number of erections per week and successful erections in which intercourse took place with different doses of Sildenafil and with placebo are shown in Figure 4. [source, 2002]
With dose optimised Sildenafil they occurred more often than once a week. [source, 2002]
Dose optimisation produced more successful erections, and more erections in total, than did 50 mg or 100 mg fixed dose Sildenafil. [source, 2002]