Latest research on Sildenafil

Sildenfail is a vasoactive agent used to treat erectile dysfunction and reduce symptoms in patients with pulmonary arterial hypertension (PAH). Sildenafil elevates levels of the second messenger, cGMP, by inhibiting its breakdown via phosphodiesterase type 5 (PDE5). PDE5 is found in particularly high concentrations in the corpus cavernosum, erectile tissue of the penis. It is also found in the retina and vascular endothelium. Increased cGMP results in vasodilation which facilitates generation and maintenance of an erection. The vasodilatory effects of sildenafil also help reduce symptoms of PAH.

Sildenafil and alcohol

Men were asked “Thinking about the times you had anal sex WITHOUT a condom in the last 12 months, how often were you (a) drunk on alcohol; (b) using poppers; (c) using Viagra or other erectile dysfunction drugs; (d) using stimulant drugs (eg, speed, Cocaine, etc); (e) using other recreational or illicit drugs (eg, Ecstasy, KETAMINE)”, with response options of always, sometimes and never. [source, 2014]
We adjusted for factors significant at the bivariate level (p<0.05), (a) alcohol, (b) poppers, (c) Viagra or other erectile dysfunction drugs and (d) stimulant or recreational/illicit drugs, and any factors associated with these. [source, 2014]
Finally, those using stimulant or recreational/illicit drugs were more likely to use alcohol (χ2=29.07, p<0.001), poppers (χ2=43.8, p<0.001), and Viagra (χ2=50.58, p<0.001). [source, 2014]
In our study, more than three-quarters always or sometimes used alcohol during UAI in the previous 12 months, one-third used poppers, one-fifth used a stimulant or other recreational/illicit drugs, and one in seven used Viagra. [source, 2014]
Within our study we found that alcohol and drug use differed by age; younger men were more likely to report using alcohol during UAI, while older men were more likely to use poppers or Viagra. [source, 2014]
Research on the association of alcohol and drug use to sexual risk behaviour remains somewhat mixed, and although there has been support for links between sexual risk and Methamphetamine and alcohol use, particularly heavy alcohol use, findings for other drugs, such as poppers and Viagra, are more varied. [source, 2014]
The pharmacokinetics of mirodenafil is not affected by alcohol, which is similar to other traditional PDE5 inhibitors (Sildenafil, Vardenafil, and tadalafil) [20,21]. [source, 2014]
The couples were instructed to perform their usual sexual activities and not to use any drugs, alcohol or medication for erectile dysfunction (i.e. Viagra) before the sexual activity as well as not to perform any paraphilic sexual activities. [source, 2013]
These questions were asked separately for alcohol, marijuana, powdered Cocaine, crack Cocaine, Heroin or other opiates, hallucinogens, Ecstasy, club drugs other than Ecstasy (e.g., ketamine/Special K, GHB, etc.), Methamphetamine, Viagra or the equivalent (excluded from the present paper’s analysis of illegal drug use), and sedatives or depressant drugs that were not prescribed by a physician. [source, 2013]
These questions were asked separately for alcohol, marijuana, powdered Cocaine, crack Cocaine, Heroin or other opiates, hallucinogens, Ecstasy, club drugs other than Ecstasy (e.g., ketamine/“Special K,” GHB, etc.), Methamphetamine, Viagra or its equivalent (excluded from the present paper's analysis of “illegal drug use”), and sedatives or depressant drugs that were not prescribed by a physician. [source, 2013]